Histopathology associated with elevated levels of growth hormone and insulin-like growth factor I in transgenic mice

C. J. Quaife, L. S. Mathews, C. A. Pinkert, Robert E Hammer, R. L. Brinster, R. D. Palmiter

Research output: Contribution to journalArticle

202 Citations (Scopus)

Abstract

Serum levels of GH and insulin-like growth factor I (IGF-I) were genetically increased to investigate the physiological activities of these proteins. Lines of mice expressing chimeric genes composed of bovine GH, human GRF, or human IGF-I coding sequences fused to the mouse metallothionein I promoter were examined for consequences of chronic exposure to high levels of these peptides. Animals with elevated serum levels of GH (either bovine GH or mouse GH) have selective splanchnomegaly coupled with glomerular sclerosis and hepatocellularmegaly. Serum levels of insulin and cholesterol are increased. In contrast (with the exception of selective enlargement of organs), the chronic expression of IGF-I results in a different pattern of abnormalities. These findings suggest that the pathogenesis of GH-related disorders is not mediated solely by IGF-I.

Original languageEnglish (US)
Pages (from-to)40-48
Number of pages9
JournalEndocrinology
Volume124
Issue number1
StatePublished - 1989

Fingerprint

Insulin-Like Growth Factor I
Transgenic Mice
Growth Hormone
Serum
Metallothionein
Sclerosis
Cholesterol
Insulin
Peptides
Genes
Proteins

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Quaife, C. J., Mathews, L. S., Pinkert, C. A., Hammer, R. E., Brinster, R. L., & Palmiter, R. D. (1989). Histopathology associated with elevated levels of growth hormone and insulin-like growth factor I in transgenic mice. Endocrinology, 124(1), 40-48.

Histopathology associated with elevated levels of growth hormone and insulin-like growth factor I in transgenic mice. / Quaife, C. J.; Mathews, L. S.; Pinkert, C. A.; Hammer, Robert E; Brinster, R. L.; Palmiter, R. D.

In: Endocrinology, Vol. 124, No. 1, 1989, p. 40-48.

Research output: Contribution to journalArticle

Quaife, CJ, Mathews, LS, Pinkert, CA, Hammer, RE, Brinster, RL & Palmiter, RD 1989, 'Histopathology associated with elevated levels of growth hormone and insulin-like growth factor I in transgenic mice', Endocrinology, vol. 124, no. 1, pp. 40-48.
Quaife, C. J. ; Mathews, L. S. ; Pinkert, C. A. ; Hammer, Robert E ; Brinster, R. L. ; Palmiter, R. D. / Histopathology associated with elevated levels of growth hormone and insulin-like growth factor I in transgenic mice. In: Endocrinology. 1989 ; Vol. 124, No. 1. pp. 40-48.
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