Hitting a moving target: Glioma stem cells demand new approaches in glioblastoma therapy

Drew A. Spencer, Brenda M. Auffinger, Jason P. Murphy, Megan E. Muroski, Jian Qiao, Yureve Gorind, Maciej S. Lesniak

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Background: Glioblastoma multiforme (GBM) continues to devastate patients and outfox investigators and clinicians despite the preponderance of research directed at its biology, pathogenesis and therapeutic advances. GBM routinely outlasts multidisciplinary treatment protocols, almost inevitably recurring in a yet more aggressive and resistant form with distinct genetic differences from the original tumor. Attempts to glean further insight into GBM point increasingly toward a subpopulation of cells with a stem-like phenotype. These cancer stem cells, similar to those now described in a variety of malignancies, are capable of tumorigenesis from a population of susceptible cells. Conclusions: Glioma stem cells have thus become a prevalent focus in GBM research for their presumed role in development, maintenance and recurrence of tumors. Glioma stem cells infiltrate the white matter surrounding tumors and often evade resection. They are uniquely suited both biochemically and environmentally to resist the best therapy currently available, intrinsically and efficiently resistant to standard chemo- and radiotherapy. These stem cells create an extremely heterogenous tumor that to date has had an answer for every therapeutic question, with continued dismal patient survival. Targeting this population of glioma stem cells may hold the long-awaited key to durable therapeutic efficacy in GBM.

Original languageEnglish (US)
Pages (from-to)236-254
Number of pages19
JournalCurrent Cancer Drug Targets
Volume17
Issue number3
DOIs
StatePublished - Mar 1 2017

Keywords

  • Chemotherapy
  • Drug targets
  • Glioblastoma multiforme
  • Glioma stem cells
  • Niches
  • Recurrence
  • Resistance

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Cancer Research

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  • Cite this

    Spencer, D. A., Auffinger, B. M., Murphy, J. P., Muroski, M. E., Qiao, J., Gorind, Y., & Lesniak, M. S. (2017). Hitting a moving target: Glioma stem cells demand new approaches in glioblastoma therapy. Current Cancer Drug Targets, 17(3), 236-254. https://doi.org/10.2174/1568009616666161215161924