HIV type 1 phenotype, tropism, and sequence patterns: Association and preference

Xiao Nan Dong, Xi Chen, Yu Chen, Ablikim Ablimit, Zi Ye, Yi Wu, Ying Hua Chen

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

In this study, the relationship between biological phenotypes, coreceptor usages, and sequence patterns of V1V2 or V3 regions on HIV-1 envelope gp 120 was carefully analyzed based on the existing isolates in the Los Alamos National Laboratory sequence database. Obviously, SI/NSI phenotypes were closely linked to the capability of HIV-1 to use coreceptor CXCR4, but not CCRS. Moreover, compared to NSI or RS isolates, SI or X4 HIV-1 isolates significantly prefer higher net charges and the loss of the N-linked glycosylation site in the V3 loop, but they show no preference in either net charge or N-linked glycosylation of the V1V2 region. In addition, no significant relationship between V1V2 length and virus tropism or phenotypes was observed.

Original languageEnglish (US)
Pages (from-to)234-238
Number of pages5
JournalAIDS Research and Human Retroviruses
Volume21
Issue number3
DOIs
StatePublished - Mar 2005

ASJC Scopus subject areas

  • Immunology
  • Virology

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    Dong, X. N., Chen, X., Chen, Y., Ablimit, A., Ye, Z., Wu, Y., & Chen, Y. H. (2005). HIV type 1 phenotype, tropism, and sequence patterns: Association and preference. AIDS Research and Human Retroviruses, 21(3), 234-238. https://doi.org/10.1089/aid.2005.21.234