HLA antigens and risk for development of pemphigus foliaceus (fogo selvagem) in endemic areas of Brazil

J. Roberto Moraes, M. Elisa Moraes, Marcelo Fernandez-Vina, Luis A. Diaz, Horacio Friedman, Iphis T. Campbell, Rosicler R. Alvarez, S. A P Sampaio, E. A. Rivitti, Peter Stastny

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Abstract

Endemic pemphigus foliaceus (EPF), is an autoimmune disease associated with production of IgG antibodies against epidermal antigens. We have tested 38 patients and 50 control subjects living in endemic areas to investigate whether HLA genes are associated with host factors that determine whether or not exposed individuals will develop this disease. A variant of HLA-DR1, an antigen common in Blacks (DRB1*0102), was found to be the main susceptibility factor (relative risk=7.3, P<0.0002). Two amino acids, in positions 85 and 86 of DRB1, distinguish DRB1*0102 from DRB1*0101. These residues appear to be involved in the formation of a functional epitope that causes T cell recognition and determines disease susceptibility. Moreover, subjects having DQw2 did not develop the disease, while the frequency of DQw2 in controls was 22% (RR=0.04, P<0.006). Thus HLA genes appear to play a crucial role in the response to an environmental factor which in this setting frequently leads to the development of autoimmune disease. An HLA-DQ allele, DQw2, appears to be associated with factors that prevent the development of the disease in exposed individuals.

Original languageEnglish (US)
Pages (from-to)388-391
Number of pages4
JournalImmunogenetics
Volume33
Issue number5-6
DOIs
StatePublished - May 1991

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Pemphigus
HLA Antigens
Brazil
Autoimmune Diseases
HLA-DR1 Antigen
HLA-DQ Antigens
T-Lymphocyte Epitopes
Disease Susceptibility
Genes
Antibody Formation
Immunoglobulin G
Alleles
Antigens
Amino Acids
Pemphigus and fogo selvagem

ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

Moraes, J. R., Moraes, M. E., Fernandez-Vina, M., Diaz, L. A., Friedman, H., Campbell, I. T., ... Stastny, P. (1991). HLA antigens and risk for development of pemphigus foliaceus (fogo selvagem) in endemic areas of Brazil. Immunogenetics, 33(5-6), 388-391. https://doi.org/10.1007/BF00216698

HLA antigens and risk for development of pemphigus foliaceus (fogo selvagem) in endemic areas of Brazil. / Moraes, J. Roberto; Moraes, M. Elisa; Fernandez-Vina, Marcelo; Diaz, Luis A.; Friedman, Horacio; Campbell, Iphis T.; Alvarez, Rosicler R.; Sampaio, S. A P; Rivitti, E. A.; Stastny, Peter.

In: Immunogenetics, Vol. 33, No. 5-6, 05.1991, p. 388-391.

Research output: Contribution to journalArticle

Moraes, JR, Moraes, ME, Fernandez-Vina, M, Diaz, LA, Friedman, H, Campbell, IT, Alvarez, RR, Sampaio, SAP, Rivitti, EA & Stastny, P 1991, 'HLA antigens and risk for development of pemphigus foliaceus (fogo selvagem) in endemic areas of Brazil', Immunogenetics, vol. 33, no. 5-6, pp. 388-391. https://doi.org/10.1007/BF00216698
Moraes JR, Moraes ME, Fernandez-Vina M, Diaz LA, Friedman H, Campbell IT et al. HLA antigens and risk for development of pemphigus foliaceus (fogo selvagem) in endemic areas of Brazil. Immunogenetics. 1991 May;33(5-6):388-391. https://doi.org/10.1007/BF00216698
Moraes, J. Roberto ; Moraes, M. Elisa ; Fernandez-Vina, Marcelo ; Diaz, Luis A. ; Friedman, Horacio ; Campbell, Iphis T. ; Alvarez, Rosicler R. ; Sampaio, S. A P ; Rivitti, E. A. ; Stastny, Peter. / HLA antigens and risk for development of pemphigus foliaceus (fogo selvagem) in endemic areas of Brazil. In: Immunogenetics. 1991 ; Vol. 33, No. 5-6. pp. 388-391.
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