HLA antigens in juvenile arthritis: Pauciarticular and polyarticular juvenile arthritis are immunogenetically distinct

Marcelo A. Fernandez-ViñA, Chester W. Fink, Peter Stastny

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Using DNA techniques, we investigated the role of HLA-DR, DQ, and DP alleles in susceptibility to juvenile arthritis (JA). We studied 2 groups of patients with JA having a different disease prognosis and course. The pauciarticular form is usually benign, while the polyarticular disease frequently leads to joint destruction and disability. Persistent pauciarticular disease developed preferentially in patients having HLA-DRw13-Dw18 and DQw6-Dw18, but these antigens did not confer susceptibility in patients whose disease converted to the polyarticular form. HLA-DPw2.1 was an additional susceptibility factor for patients with JA of pauciarticular onset. In the polyarticular form of JA, HLA-DPw3 was the major factor for susceptibility, giving a relative risk of 10.3 (P < 0.0001). In addition, we found that DRw8.1 and DQw4 were increased, and HLA-DR4 was markedly decreased, in patients with pauciarticular and polyarticular disease. These results indicate that in addition to some shared factors, distinct HLA class II alleles are important in pauciarticular or polyarticular JA. We conclude that typing with oligonucleotide probes may be useful in predicting the outcome in some children with arthritis.

Original languageEnglish (US)
Pages (from-to)1787-1794
Number of pages8
JournalArthritis and Rheumatism
Volume33
Issue number12
StatePublished - Dec 1990

Fingerprint

Juvenile Arthritis
HLA Antigens
Alleles
HLA-DP Antigens
HLA-DR4 Antigen
HLA-DQ Antigens
Oligonucleotide Probes
HLA-DR Antigens
Arthritis
Joints
Antigens
DNA

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

HLA antigens in juvenile arthritis : Pauciarticular and polyarticular juvenile arthritis are immunogenetically distinct. / Fernandez-ViñA, Marcelo A.; Fink, Chester W.; Stastny, Peter.

In: Arthritis and Rheumatism, Vol. 33, No. 12, 12.1990, p. 1787-1794.

Research output: Contribution to journalArticle

Fernandez-ViñA, Marcelo A. ; Fink, Chester W. ; Stastny, Peter. / HLA antigens in juvenile arthritis : Pauciarticular and polyarticular juvenile arthritis are immunogenetically distinct. In: Arthritis and Rheumatism. 1990 ; Vol. 33, No. 12. pp. 1787-1794.
@article{a287e9b4de35421082c3d4c4b447e642,
title = "HLA antigens in juvenile arthritis: Pauciarticular and polyarticular juvenile arthritis are immunogenetically distinct",
abstract = "Using DNA techniques, we investigated the role of HLA-DR, DQ, and DP alleles in susceptibility to juvenile arthritis (JA). We studied 2 groups of patients with JA having a different disease prognosis and course. The pauciarticular form is usually benign, while the polyarticular disease frequently leads to joint destruction and disability. Persistent pauciarticular disease developed preferentially in patients having HLA-DRw13-Dw18 and DQw6-Dw18, but these antigens did not confer susceptibility in patients whose disease converted to the polyarticular form. HLA-DPw2.1 was an additional susceptibility factor for patients with JA of pauciarticular onset. In the polyarticular form of JA, HLA-DPw3 was the major factor for susceptibility, giving a relative risk of 10.3 (P < 0.0001). In addition, we found that DRw8.1 and DQw4 were increased, and HLA-DR4 was markedly decreased, in patients with pauciarticular and polyarticular disease. These results indicate that in addition to some shared factors, distinct HLA class II alleles are important in pauciarticular or polyarticular JA. We conclude that typing with oligonucleotide probes may be useful in predicting the outcome in some children with arthritis.",
author = "Fernandez-Vi{\~n}A, {Marcelo A.} and Fink, {Chester W.} and Peter Stastny",
year = "1990",
month = "12",
language = "English (US)",
volume = "33",
pages = "1787--1794",
journal = "Arthritis and Rheumatology",
issn = "2326-5191",
publisher = "John Wiley and Sons Ltd",
number = "12",

}

TY - JOUR

T1 - HLA antigens in juvenile arthritis

T2 - Pauciarticular and polyarticular juvenile arthritis are immunogenetically distinct

AU - Fernandez-ViñA, Marcelo A.

AU - Fink, Chester W.

AU - Stastny, Peter

PY - 1990/12

Y1 - 1990/12

N2 - Using DNA techniques, we investigated the role of HLA-DR, DQ, and DP alleles in susceptibility to juvenile arthritis (JA). We studied 2 groups of patients with JA having a different disease prognosis and course. The pauciarticular form is usually benign, while the polyarticular disease frequently leads to joint destruction and disability. Persistent pauciarticular disease developed preferentially in patients having HLA-DRw13-Dw18 and DQw6-Dw18, but these antigens did not confer susceptibility in patients whose disease converted to the polyarticular form. HLA-DPw2.1 was an additional susceptibility factor for patients with JA of pauciarticular onset. In the polyarticular form of JA, HLA-DPw3 was the major factor for susceptibility, giving a relative risk of 10.3 (P < 0.0001). In addition, we found that DRw8.1 and DQw4 were increased, and HLA-DR4 was markedly decreased, in patients with pauciarticular and polyarticular disease. These results indicate that in addition to some shared factors, distinct HLA class II alleles are important in pauciarticular or polyarticular JA. We conclude that typing with oligonucleotide probes may be useful in predicting the outcome in some children with arthritis.

AB - Using DNA techniques, we investigated the role of HLA-DR, DQ, and DP alleles in susceptibility to juvenile arthritis (JA). We studied 2 groups of patients with JA having a different disease prognosis and course. The pauciarticular form is usually benign, while the polyarticular disease frequently leads to joint destruction and disability. Persistent pauciarticular disease developed preferentially in patients having HLA-DRw13-Dw18 and DQw6-Dw18, but these antigens did not confer susceptibility in patients whose disease converted to the polyarticular form. HLA-DPw2.1 was an additional susceptibility factor for patients with JA of pauciarticular onset. In the polyarticular form of JA, HLA-DPw3 was the major factor for susceptibility, giving a relative risk of 10.3 (P < 0.0001). In addition, we found that DRw8.1 and DQw4 were increased, and HLA-DR4 was markedly decreased, in patients with pauciarticular and polyarticular disease. These results indicate that in addition to some shared factors, distinct HLA class II alleles are important in pauciarticular or polyarticular JA. We conclude that typing with oligonucleotide probes may be useful in predicting the outcome in some children with arthritis.

UR - http://www.scopus.com/inward/record.url?scp=0025689615&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025689615&partnerID=8YFLogxK

M3 - Article

C2 - 2261000

AN - SCOPUS:0025689615

VL - 33

SP - 1787

EP - 1794

JO - Arthritis and Rheumatology

JF - Arthritis and Rheumatology

SN - 2326-5191

IS - 12

ER -