HLA-DPB1 alleles in a population from South China

Michela Falco, Yiping Sun, Marcelo A. Fernandez-Viña, Peter Stastny

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Using the polymerase chain reaction (PCR) and hybridization with oligonucleotide probes, we analyzed the distribution of DPB1 alleles in 99 healthy unrelated individuals from the city of Guangzhou (Canton), South China. Twelve different DPB1 alleles were found in this panel. The most common allele was DPB1*0501 (62.6%). Other major alleles detected included DPB1*02 (DPB1*0201 and DPB1*0202), DPB1*1301, DPB1*0401, and a recently described allele, designated DPB1*2101. The hybridization pattern of DPB1*2101 showed that this allele shared sequences with DPB1*0301 and DPB1*0601 in the A and F hypervariable regions, while the C, D, and E regions were identical to those of DPB1*0202. DPB1*2101 was observed in 11% of the subjects tested. It was found to be in strong linkage dis-equilibrium with DRB1*1202. In family studies, segregation of the haplotype DRB1*1202, DRB3*0301, DQA1*0601, DQB1*0301, DPB1*2101 was observed. The second exon of DPB1*2101 was sequenced from codon 8 to codon 90 and the sequence, inferred from the pattern of hybridization, was confirmed. DPB1*0301, DPB1*0402, DPB1*0101, DPB1*1401, DPB1*1901, and another recently recognized allele, now designated DPB1*2401, were detected with low frequencies. DPB1*2401 had the same hybridization pattern as DPB1*0501 except for a probe that matches codons 85-90. In this region, DPB1*2401 encoded the amino acid sequence GPMTLQ instead of EAVTLQ as in DPB1*0501.

Original languageEnglish (US)
Pages (from-to)251-256
Number of pages6
JournalImmunogenetics
Volume37
Issue number4
DOIs
StatePublished - Jan 1993

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China
Alleles
Population
Codon
Oligonucleotide Probes
HLA-DPB1 antigen
Haplotypes
Amino Acid Sequence
Exons
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

Falco, M., Sun, Y., Fernandez-Viña, M. A., & Stastny, P. (1993). HLA-DPB1 alleles in a population from South China. Immunogenetics, 37(4), 251-256. https://doi.org/10.1007/BF00187450

HLA-DPB1 alleles in a population from South China. / Falco, Michela; Sun, Yiping; Fernandez-Viña, Marcelo A.; Stastny, Peter.

In: Immunogenetics, Vol. 37, No. 4, 01.1993, p. 251-256.

Research output: Contribution to journalArticle

Falco, M, Sun, Y, Fernandez-Viña, MA & Stastny, P 1993, 'HLA-DPB1 alleles in a population from South China', Immunogenetics, vol. 37, no. 4, pp. 251-256. https://doi.org/10.1007/BF00187450
Falco M, Sun Y, Fernandez-Viña MA, Stastny P. HLA-DPB1 alleles in a population from South China. Immunogenetics. 1993 Jan;37(4):251-256. https://doi.org/10.1007/BF00187450
Falco, Michela ; Sun, Yiping ; Fernandez-Viña, Marcelo A. ; Stastny, Peter. / HLA-DPB1 alleles in a population from South China. In: Immunogenetics. 1993 ; Vol. 37, No. 4. pp. 251-256.
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