TY - JOUR
T1 - HLA–DPB1*0301 is a Major Risk Factor for Rheumatoid Factor–Negative Adult Rheumatoid Arthritis
AU - Gao, Xiaojiang
AU - Fernandez-Vina, Marcelo
AU - Olsen, Nancy J.
AU - Pincus, Theodore
AU - Stastny, Peter
PY - 1991/10/10
Y1 - 1991/10/10
N2 - HLA–DPB1 alleles were determined using the polymerase chain reaction and allele‐specific oligonucleotide probes in Caucasoid patients with rheumatoid arthritis (RA) and in healthy controls. DPB1*0301 was found to be increased in seronegative patients (50.0% versus 10.8% in controls; relative risk = 8.3, P < 0.0001). With our previous finding that DPB1*0301 is increased in seronegative children with polyarticularonset arthritis, the results suggest a relationship between this disease and seronegative RA in adults.
AB - HLA–DPB1 alleles were determined using the polymerase chain reaction and allele‐specific oligonucleotide probes in Caucasoid patients with rheumatoid arthritis (RA) and in healthy controls. DPB1*0301 was found to be increased in seronegative patients (50.0% versus 10.8% in controls; relative risk = 8.3, P < 0.0001). With our previous finding that DPB1*0301 is increased in seronegative children with polyarticularonset arthritis, the results suggest a relationship between this disease and seronegative RA in adults.
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U2 - 10.1002/art.1780341016
DO - 10.1002/art.1780341016
M3 - Article
C2 - 1930320
AN - SCOPUS:0025924936
SN - 0004-3591
VL - 34
SP - 1310
EP - 1312
JO - Arthritis & Rheumatism
JF - Arthritis & Rheumatism
IS - 10
ER -