HLA in Singapore Chinese with rheumatoid arthritis

M. L. Boey, G. B. Wee, C. Mohan, H. S. Howe, S. H. Chan, P. H. Feng

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The HLA-A, B, C, DR and DQ antigens were determined in 50 Singapore Chinese patients with rheumatoid arthritis (RA). There was a significant increase in the prevalence of HLA-Bw46, DRw53 and DQ3 in patients with RA. The linkage disequilibrium between Bw46 and DRw53 explains this association. This major histocompatibility complex association differs from the HLA-DR4 link in Caucasian populations and suggests that RA is an immunogenetically heterogeneous disease.

Original languageEnglish (US)
Pages (from-to)1517-1519
Number of pages3
JournalJournal of Rheumatology
Volume19
Issue number10
StatePublished - Jan 1 1992

Keywords

  • Chinese
  • HLA
  • rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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    Boey, M. L., Wee, G. B., Mohan, C., Howe, H. S., Chan, S. H., & Feng, P. H. (1992). HLA in Singapore Chinese with rheumatoid arthritis. Journal of Rheumatology, 19(10), 1517-1519.