HLA–DPB1*0301 is a Major Risk Factor for Rheumatoid Factor–Negative Adult Rheumatoid Arthritis

Xiaojiang Gao, Marcelo Fernandez-Vina, Nancy J. Olsen, Theodore Pincus, Peter Stastny

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

HLA–DPB1 alleles were determined using the polymerase chain reaction and allele‐specific oligonucleotide probes in Caucasoid patients with rheumatoid arthritis (RA) and in healthy controls. DPB1*0301 was found to be increased in seronegative patients (50.0% versus 10.8% in controls; relative risk = 8.3, P < 0.0001). With our previous finding that DPB1*0301 is increased in seronegative children with polyarticularonset arthritis, the results suggest a relationship between this disease and seronegative RA in adults.

Original languageEnglish (US)
Pages (from-to)1310-1312
Number of pages3
JournalArthritis & Rheumatism
Volume34
Issue number10
DOIs
StatePublished - Oct 10 1991

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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