HMGB1 as an autophagy sensor in oxidative stress

Rui Kang, Kristen M. Livesey, Herbert J. Zeh, Michael T. Lotze, Daolin Tang

Research output: Contribution to journalShort survey

51 Scopus citations

Abstract

High mobility group box 1 (HMGB1) is a DNA-binding nuclear protein, actively released following cytokine stimulation as well as passively during cell injury and death. Autophagy is a tightly regulated cellular stress pathway involving the lysosomal degradation of cytoplasmic organelles or proteins. Organisms respond to oxidative injury by orchestrating stress responses such as autophagy to prevent further damage. Recently, we reported that HMGB1 is an autophagy sensor in the presence of oxidative stress. Hydrogen peroxide (H 2O2) and loss of superoxide dismutase 1 (SOD1)-mediated oxidative stress promotes cytosolic HMGB1 expression and extracellular release. Inhibition of HMGB1 release or loss of HMGB1 decreases the number of autolysosomes and autophagic flux in human and mouse cell lines under conditions of oxidative stress. These findings provide insight into how HMGB1, a damage associated molecular pattern (DAMP), triggers autophagy as defense mechanism under conditions of cellular stress.

Original languageEnglish (US)
Pages (from-to)904-906
Number of pages3
JournalAutophagy
Volume7
Issue number8
DOIs
Publication statusPublished - Aug 2011
Externally publishedYes

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Keywords

  • Autophagy
  • HMGB1
  • MAPK
  • Oxidative stress
  • PARP
  • SOD

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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