HMGB1-dependent and -independent autophagy

Xiaofang Sun, Daolin Tang

Research output: Contribution to journalComment/debate

41 Scopus citations

Abstract

HMGB1 (high mobility group box 1) is a multifunctional, ubiquitous protein located inside and outside cells that plays a critical role in various physiological and pathological processes including cell development, differentiation, inflammation, immunity, metastasis, metabolism, and death. Increasing evidence demonstrates that HMGB1-dependent autophagy promotes chemotherapy resistance, sustains tumor metabolism requirements and T cell survival, prevents polyglutamine aggregates and excitotoxicity, and protects against endotoxemia, bacterial infection, and ischemia-reperfusion injury in vitro or in vivo. In contrast, HMGB1 may not be required for autophagy in some organs such as the liver and heart. Understanding HMGB1-dependent and -independent autophagy in more detail will provide insight into the integrated stress response and guide HMGB1-based therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)1873-1876
Number of pages4
JournalAutophagy
Volume10
Issue number10
DOIs
StatePublished - Oct 1 2014
Externally publishedYes

Keywords

  • Autophagy
  • HMGB1
  • Knockin
  • Knockout
  • Phenotype

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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