Abstract
HMGB1 (high mobility group box 1) is a multifunctional, ubiquitous protein located inside and outside cells that plays a critical role in various physiological and pathological processes including cell development, differentiation, inflammation, immunity, metastasis, metabolism, and death. Increasing evidence demonstrates that HMGB1-dependent autophagy promotes chemotherapy resistance, sustains tumor metabolism requirements and T cell survival, prevents polyglutamine aggregates and excitotoxicity, and protects against endotoxemia, bacterial infection, and ischemia-reperfusion injury in vitro or in vivo. In contrast, HMGB1 may not be required for autophagy in some organs such as the liver and heart. Understanding HMGB1-dependent and -independent autophagy in more detail will provide insight into the integrated stress response and guide HMGB1-based therapeutic intervention.
Original language | English (US) |
---|---|
Pages (from-to) | 1873-1876 |
Number of pages | 4 |
Journal | Autophagy |
Volume | 10 |
Issue number | 10 |
DOIs |
|
State | Published - Oct 1 2014 |
Externally published | Yes |
Keywords
- Autophagy
- HMGB1
- Knockin
- Knockout
- Phenotype
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology