TY - JOUR
T1 - HMGB1 in cancer
T2 - Good, bad, or both?
AU - Kang, Rui
AU - Zhang, Qiuhong
AU - Zeh, Herbert J.
AU - Lotze, Michael T.
AU - Tang, Daolin
PY - 2013/8/1
Y1 - 2013/8/1
N2 - Forty years ago, high mobility group box 1 (HMGB1) was discovered in calf thymus and named according to its electrophoretic mobility in polyacrylamide gels. Now, we know that HMGB1performs dual functions. Inside the cell, HMGB1 is a highly conserved chromosomal protein acting as a DNA chaperone. Outside of the cell, HMGB1 is a prototypical damage-Associated molecular pattern, acting with cytokines, chemokines, and growth factors. During tumor development and in cancer therapy, HMGB1 has been reported to play paradoxical roles in promoting both cell survival and death by regulating multiple signaling pathways, including inflammation, immunity, genome stability, proliferation, metastasis, metabolism, apoptosis, and autophagy. Here, we review the current knowledge of both HMGB10s oncogenic and tumor-suppressive roles and the potential strategies that target HMGB1 for the prevention and treatment of cancer.
AB - Forty years ago, high mobility group box 1 (HMGB1) was discovered in calf thymus and named according to its electrophoretic mobility in polyacrylamide gels. Now, we know that HMGB1performs dual functions. Inside the cell, HMGB1 is a highly conserved chromosomal protein acting as a DNA chaperone. Outside of the cell, HMGB1 is a prototypical damage-Associated molecular pattern, acting with cytokines, chemokines, and growth factors. During tumor development and in cancer therapy, HMGB1 has been reported to play paradoxical roles in promoting both cell survival and death by regulating multiple signaling pathways, including inflammation, immunity, genome stability, proliferation, metastasis, metabolism, apoptosis, and autophagy. Here, we review the current knowledge of both HMGB10s oncogenic and tumor-suppressive roles and the potential strategies that target HMGB1 for the prevention and treatment of cancer.
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U2 - 10.1158/1078-0432.CCR-13-0495
DO - 10.1158/1078-0432.CCR-13-0495
M3 - Article
C2 - 23723299
AN - SCOPUS:84881231803
SN - 1078-0432
VL - 19
SP - 4046
EP - 4057
JO - Clinical Cancer Research
JF - Clinical Cancer Research
IS - 15
ER -