HMT, encoded by H-2M3, is a neoclassical major histocompatibility class I antigen

Chyung Ru Wang, Kirsten Fischer Lindahl

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

H-2M3 encodes HMT, the major histocompatibility complex (MHC) class I heavy chain of the maternally transmitted antigen (Mta). Like classical MHC class I genes, the expression of M3 can be stimulated by γ-interferon and its message can be detected from mid-gestational embryos (day 8) through adulthood. HMTb, a nonimmunogenic allelic form of HMT, differs from the common HMTa molecule by four amino acids, of which only two (residues 31 and 95) are located in the α1 and α2 domains that form the peptide-binding groove. Recognition of site-directed mutants by Mta-specific cytotoxic T lymphocytes was hardly affected by the substitution of Met for Val31 but was abolished by the substitution of GIl for Leu95, which is located in the β-sheet floor of the peptide-binding groove. Thus a single amino acid difference is responsible for the immunological silence of HMTb.

Original languageEnglish (US)
Pages (from-to)2784-2788
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume90
Issue number7
DOIs
StatePublished - Apr 1 1993

Keywords

  • Cytotoxic T lymphocytes
  • Gene expression
  • Interferon γ
  • Peptide presentation
  • Site-directed mutagenesis

ASJC Scopus subject areas

  • General

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