HNF-4α: From MODY to late-onset type 2 diabetes

Rana K Gupta, Klaus H. Kaestner

Research output: Contribution to journalShort surveypeer-review

59 Scopus citations

Abstract

Maturity-onset diabetes of the young (MODY) is a rare subtype of type 2 diabetes that is characterized by autosomal-dominant inheritance and can be caused by mutations in hepatocyte nuclear factor 4α (HNF-4α). Odom and colleagues have combined chromatin immunoprecipitation with promoter microarrays to identify numerous promoters occupied by HNF-4α in the human liver and islet, suggesting a very broad role for HNF-4α in glucose homeostasis. This notion is supported by recent genetic studies linking HNF-4α to the much more common late-onset type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)521-524
Number of pages4
JournalTrends in Molecular Medicine
Volume10
Issue number11
DOIs
StatePublished - Nov 2004

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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