Abstract
Maturity-onset diabetes of the young (MODY) is a rare subtype of type 2 diabetes that is characterized by autosomal-dominant inheritance and can be caused by mutations in hepatocyte nuclear factor 4α (HNF-4α). Odom and colleagues have combined chromatin immunoprecipitation with promoter microarrays to identify numerous promoters occupied by HNF-4α in the human liver and islet, suggesting a very broad role for HNF-4α in glucose homeostasis. This notion is supported by recent genetic studies linking HNF-4α to the much more common late-onset type 2 diabetes.
Original language | English (US) |
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Pages (from-to) | 521-524 |
Number of pages | 4 |
Journal | Trends in Molecular Medicine |
Volume | 10 |
Issue number | 11 |
DOIs | |
State | Published - Nov 2004 |
ASJC Scopus subject areas
- Molecular Medicine
- Molecular Biology