Homologies between signal transducing G proteins and ras gene products

James B. Hurley, Melvin I. Simon, David B. Teplow, Janet D. Robishaw, Alfred G. Gilman

Research output: Contribution to journalArticle

268 Scopus citations


The guanosine triphosphate-binding proteins (G proteins) found in a variety of tissues transduce signals generated by ligand binding to cell surface receptors into changes in intracellular metabolism. Amino acid sequences of peptides prepared by partial proteolysis of the α subunit of a bovine brain G protein and the α subunit of rod outer-segment transducin were determined. The two proteins show regions of sequence identity as well as regions of diversity. A portion of the amino-terminal peptide sequence of each protein is highly homologous with the corresponding region in the ras protein (a protooncogene product). These similarities suggest that G proteins and ras proteins may have analogous functions.

Original languageEnglish (US)
Pages (from-to)860-862
Number of pages3
Issue number4676
StatePublished - Jan 1 1984

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    Hurley, J. B., Simon, M. I., Teplow, D. B., Robishaw, J. D., & Gilman, A. G. (1984). Homologies between signal transducing G proteins and ras gene products. Science, 226(4676), 860-862. https://doi.org/10.1126/science.6436980