Homozygous deletion scanning of the lung cancer genome at a 100-kb resolution

Kazuhiro Nagayama, Takashi Kohno, Masanori Sato, Yasuhito Arai, John D. Minna, Jun Yokota

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Whole genome scanning of 43 lung cancer cell lines at a 100-kb resolution led to identification of 51 genomic regions with homozygous deletions (HDs). The regions contained 113 genes, including two known tumor suppressor genes, RBI (RB) and CDKN2A (p16), and eight genes previously reported as being candidate tumor suppressor genes, such as PTPRD and LRP1B. Three miRNA genes, MIRNLET7C (let-7c), MIRN99A (hsa-mir-99a), and MIRN125B2 (hsa-mir-125b-2), were also mapped in a region with HD at 21q11-q21. The present study provides a list of protein- and miRNA-encoding genes whose inactivation is possibly involved in lung carcinogenesis. This article contains Supplementary Material available at http://www.interscience.wiley.com/jpages/1045-2257/suppmat.

Original languageEnglish (US)
Pages (from-to)1000-1010
Number of pages11
JournalGenes Chromosomes and Cancer
Volume46
Issue number11
DOIs
StatePublished - Nov 2007

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Tumor Suppressor Genes
MicroRNAs
Lung Neoplasms
Genome
p16 Genes
Gene Silencing
Genes
Carcinogenesis
Cell Line
Lung
Proteins
human MIRN99 microRNA

ASJC Scopus subject areas

  • Cancer Research
  • Genetics

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Homozygous deletion scanning of the lung cancer genome at a 100-kb resolution. / Nagayama, Kazuhiro; Kohno, Takashi; Sato, Masanori; Arai, Yasuhito; Minna, John D.; Yokota, Jun.

In: Genes Chromosomes and Cancer, Vol. 46, No. 11, 11.2007, p. 1000-1010.

Research output: Contribution to journalArticle

Nagayama, Kazuhiro ; Kohno, Takashi ; Sato, Masanori ; Arai, Yasuhito ; Minna, John D. ; Yokota, Jun. / Homozygous deletion scanning of the lung cancer genome at a 100-kb resolution. In: Genes Chromosomes and Cancer. 2007 ; Vol. 46, No. 11. pp. 1000-1010.
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