Homozygous deletions at 3p12 in breast and lung cancer

Vasi Sundaresan, Grace Chung, Amanda Heppell-Parton, J. Xiong, Catherine Grundy, Ian Roberts, Louise James, Anthony Cahn, Anthony Bench, Jenny Douglas, John Minna, Yoshitaka Sekido, Michael Lerman, Farida Latif, Jonas Bergh, Hua Li, Nick Lowe, Donald Ogilvie, Pamela Rabbitts

Research output: Contribution to journalArticle

89 Scopus citations

Abstract

We have constructed a physical map of the region homozygously deleted in the U2020 cell line at 3p12, including the location of putative CpG islands. Adjacent to one of these islands, we have identified and cloned a new gene (DUTT1) and used probes from this gene to detect two other homozygous deletions occurring in lung and breast carcinomas: the smallest deletion is within the gene itself and would result in a truncated protein. The DUTT1 gene is a member of the neural cell adhesion molecule family, although its widespread expression suggests it plays a less specialized role compared to other members of the family.

Original languageEnglish (US)
Pages (from-to)1723-1729
Number of pages7
JournalOncogene
Volume17
Issue number13
DOIs
StatePublished - Oct 1 1998

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Keywords

  • DUTT1/Hrobo-1
  • Familial non-specific dementia
  • Lung cancer
  • Tumour suppressor gene
  • U2020 deletion

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Sundaresan, V., Chung, G., Heppell-Parton, A., Xiong, J., Grundy, C., Roberts, I., James, L., Cahn, A., Bench, A., Douglas, J., Minna, J., Sekido, Y., Lerman, M., Latif, F., Bergh, J., Li, H., Lowe, N., Ogilvie, D., & Rabbitts, P. (1998). Homozygous deletions at 3p12 in breast and lung cancer. Oncogene, 17(13), 1723-1729. https://doi.org/10.1038/sj.onc.1202103