TY - JOUR
T1 - Hormonal, metabolic, and cardiovascular responses to static exercise in humans
T2 - Influence of epidural anesthesia
AU - Kjaer, M.
AU - Secher, N. H.
AU - Bach, F. W.
AU - Galbo, H.
AU - Reeves, D. R.
AU - Mitchell, J. H.
PY - 1991
Y1 - 1991
N2 - To determine the role of reflex neural mechanisms for hormonal, metabolic, heart rate (HR), and blood pressure (MABP) changes during static exercise, seven healthy young males performed 10-min periods of two-legged static knee extension both during control and during epidural anesthesia. Comparisons were made at identical absolute (29 Nm) and relative [15% maximal voluntary contraction (MVC)] force. Afferent nerve blockade was verified by hypesthesia below T10-T12 and attenuated postexercise ischemic pressor response. Leg strength was reduced to 67 ± 5% of control. At same relative force, increases in MABP and HR occurred more rapidly without than with epidural anesthesia (P < 0.05). This difference was diminished during identical absolute force. Changes in plasma concentrations of catecholamines followed the pattern of HR and MABP responses, with differences between epidural and control experiments being most pronounced early in the work period. Plasma β-endorphin was elevated only after control exercise. No response at 15% MVC was found for growth hormone, adrenocorticotropic hormone, insulin, glucagon, cortisol, glycerol, free fatty acids, or glucose (P > 0.05). In conclusion, during static exercise with large muscle groups and moderate relative force, modest changes in plasma hormones and metabolites take place. Furthermore, afferent nervous feedback from contracting muscles is important in regulation of blood pressure, heart rate, and catecholamine responses during static exercise in humans.
AB - To determine the role of reflex neural mechanisms for hormonal, metabolic, heart rate (HR), and blood pressure (MABP) changes during static exercise, seven healthy young males performed 10-min periods of two-legged static knee extension both during control and during epidural anesthesia. Comparisons were made at identical absolute (29 Nm) and relative [15% maximal voluntary contraction (MVC)] force. Afferent nerve blockade was verified by hypesthesia below T10-T12 and attenuated postexercise ischemic pressor response. Leg strength was reduced to 67 ± 5% of control. At same relative force, increases in MABP and HR occurred more rapidly without than with epidural anesthesia (P < 0.05). This difference was diminished during identical absolute force. Changes in plasma concentrations of catecholamines followed the pattern of HR and MABP responses, with differences between epidural and control experiments being most pronounced early in the work period. Plasma β-endorphin was elevated only after control exercise. No response at 15% MVC was found for growth hormone, adrenocorticotropic hormone, insulin, glucagon, cortisol, glycerol, free fatty acids, or glucose (P > 0.05). In conclusion, during static exercise with large muscle groups and moderate relative force, modest changes in plasma hormones and metabolites take place. Furthermore, afferent nervous feedback from contracting muscles is important in regulation of blood pressure, heart rate, and catecholamine responses during static exercise in humans.
KW - Arterial blood pressure
KW - Catecholamines
KW - Epinephrine
KW - Glucagon
KW - Growth hormone
KW - Heart rate
KW - Insulin
KW - Metabolic regulation
KW - Norepinephrine
KW - β-endorphin
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U2 - 10.1152/ajpendo.1991.261.2.e214
DO - 10.1152/ajpendo.1991.261.2.e214
M3 - Article
C2 - 1872383
AN - SCOPUS:0025997762
SN - 0002-9513
VL - 261
SP - E214-E220
JO - American Journal of Physiology - Endocrinology and Metabolism
JF - American Journal of Physiology - Endocrinology and Metabolism
IS - 2 24-2
ER -