Hormone production during pregnancy in the primigravid patient. I. Plasma levels of progesterone and 5α-pregnane-3,20-dione throughout pregnancy of normal women and women who developed pregnancy-induced hypertension

C. R. Parker, R. B. Evereti, J. G. Quirk, P. J. Whalley, N. F. Gant

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The plasma concentrations of progesterone and 5α-pregnane-3,20-dione (5α-dihydroprogesterone) were measured from as early as 12 weeks through 41 weeks of gestation in primigravid women. Two groups of primigravid women were assessed, those with uncomplicated pregnancies and those who developed pregnancy-induced hypertension. Plasma levels of progesterone and 5α-dihydroprogesterone rose progressively throughout gestation in both groups of women. The ratio of the level of progesterone to that of 5α-dihydroprogesterone in individual plasma samples of women with uncomplicated pregnancies was 7.0 from 12 to 15 weeks' gestation while at 35 to 41 weeks' gestation the ratio had declined to 4.6. Similar results were obtained in plasma samples of women who ultimately developed pregnancy-induced hypertension. Since no differences in plasma levels of progesterone or 5α-dihydroprogesterone were detected between primigravid women with uncomplicated pregnancies and those who developed pregnancy-induced hypertension, we conclude that neither progesterone nor 5α-dihydroprogesterone concentrations in plasma are of value in identifying women at risk of developing pregnancy-induced hypertension.

Original languageEnglish (US)
Pages (from-to)778-782
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume135
Issue number6
StatePublished - Nov 15 1979

Fingerprint

Pregnanes
Pregnancy Induced Hypertension
20-alpha-Dihydroprogesterone
Progesterone
Hormones
Pregnancy

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

@article{ce6c66f4157241938ca7f9640da11f41,
title = "Hormone production during pregnancy in the primigravid patient. I. Plasma levels of progesterone and 5α-pregnane-3,20-dione throughout pregnancy of normal women and women who developed pregnancy-induced hypertension",
abstract = "The plasma concentrations of progesterone and 5α-pregnane-3,20-dione (5α-dihydroprogesterone) were measured from as early as 12 weeks through 41 weeks of gestation in primigravid women. Two groups of primigravid women were assessed, those with uncomplicated pregnancies and those who developed pregnancy-induced hypertension. Plasma levels of progesterone and 5α-dihydroprogesterone rose progressively throughout gestation in both groups of women. The ratio of the level of progesterone to that of 5α-dihydroprogesterone in individual plasma samples of women with uncomplicated pregnancies was 7.0 from 12 to 15 weeks' gestation while at 35 to 41 weeks' gestation the ratio had declined to 4.6. Similar results were obtained in plasma samples of women who ultimately developed pregnancy-induced hypertension. Since no differences in plasma levels of progesterone or 5α-dihydroprogesterone were detected between primigravid women with uncomplicated pregnancies and those who developed pregnancy-induced hypertension, we conclude that neither progesterone nor 5α-dihydroprogesterone concentrations in plasma are of value in identifying women at risk of developing pregnancy-induced hypertension.",
author = "Parker, {C. R.} and Evereti, {R. B.} and Quirk, {J. G.} and Whalley, {P. J.} and Gant, {N. F.}",
year = "1979",
month = "11",
day = "15",
language = "English (US)",
volume = "135",
pages = "778--782",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "6",

}

TY - JOUR

T1 - Hormone production during pregnancy in the primigravid patient. I. Plasma levels of progesterone and 5α-pregnane-3,20-dione throughout pregnancy of normal women and women who developed pregnancy-induced hypertension

AU - Parker, C. R.

AU - Evereti, R. B.

AU - Quirk, J. G.

AU - Whalley, P. J.

AU - Gant, N. F.

PY - 1979/11/15

Y1 - 1979/11/15

N2 - The plasma concentrations of progesterone and 5α-pregnane-3,20-dione (5α-dihydroprogesterone) were measured from as early as 12 weeks through 41 weeks of gestation in primigravid women. Two groups of primigravid women were assessed, those with uncomplicated pregnancies and those who developed pregnancy-induced hypertension. Plasma levels of progesterone and 5α-dihydroprogesterone rose progressively throughout gestation in both groups of women. The ratio of the level of progesterone to that of 5α-dihydroprogesterone in individual plasma samples of women with uncomplicated pregnancies was 7.0 from 12 to 15 weeks' gestation while at 35 to 41 weeks' gestation the ratio had declined to 4.6. Similar results were obtained in plasma samples of women who ultimately developed pregnancy-induced hypertension. Since no differences in plasma levels of progesterone or 5α-dihydroprogesterone were detected between primigravid women with uncomplicated pregnancies and those who developed pregnancy-induced hypertension, we conclude that neither progesterone nor 5α-dihydroprogesterone concentrations in plasma are of value in identifying women at risk of developing pregnancy-induced hypertension.

AB - The plasma concentrations of progesterone and 5α-pregnane-3,20-dione (5α-dihydroprogesterone) were measured from as early as 12 weeks through 41 weeks of gestation in primigravid women. Two groups of primigravid women were assessed, those with uncomplicated pregnancies and those who developed pregnancy-induced hypertension. Plasma levels of progesterone and 5α-dihydroprogesterone rose progressively throughout gestation in both groups of women. The ratio of the level of progesterone to that of 5α-dihydroprogesterone in individual plasma samples of women with uncomplicated pregnancies was 7.0 from 12 to 15 weeks' gestation while at 35 to 41 weeks' gestation the ratio had declined to 4.6. Similar results were obtained in plasma samples of women who ultimately developed pregnancy-induced hypertension. Since no differences in plasma levels of progesterone or 5α-dihydroprogesterone were detected between primigravid women with uncomplicated pregnancies and those who developed pregnancy-induced hypertension, we conclude that neither progesterone nor 5α-dihydroprogesterone concentrations in plasma are of value in identifying women at risk of developing pregnancy-induced hypertension.

UR - http://www.scopus.com/inward/record.url?scp=0018674308&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018674308&partnerID=8YFLogxK

M3 - Article

C2 - 495678

AN - SCOPUS:0018674308

VL - 135

SP - 778

EP - 782

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 6

ER -