Hospitalized hemorrhagic stroke patients with renal insufficiency: Clinical characteristics, care patterns, and outcomes

Bruce Ovbiagele, Lee H. Schwamm, Eric E. Smith, Maria V. Grau-Sepulveda, Jeffrey L. Saver, Deepak L. Bhatt, Adrian F. Hernandez, Eric D. Peterson, Gregg C. Fonarow

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Background: There is a paucity of information on clinical characteristics, care patterns, and clinical outcomes for hospitalized intracerebral hemorrhage (ICH) patients with chronic kidney disease (CKD). We assessed characteristics, care processes, and in-hospital outcome among ICH patients with CKD in the Get With the Guidelines-Stroke (GWTG-Stroke) program.

Methods: We analyzed 113,059 ICH patients hospitalized at 1472 US centers participating in the GWTGStroke program between January 2009 and December 2012. In-hospital mortality and use of 2 predefined ICH performance measures were examined based on glomerular filtration rate. Renal dysfunction was categorized as a dichotomous (1CKD 5 estimated glomerular filtration rate<60) or rank ordered variable as CKD (<60), and by clinical stage: (normal [≥90], mild [≥60 -<90], moderate [≥30<60], severe [≥15<30], and/or kidney failure [<15 or dialysis]).

Results: There were 33,219 (29%) ICH patients with CKD. Patients with CKD were more likely to be older, female, and with comorbid conditions such as diabetes. Compared with patients with normal kidney function, those with CKD were slightly less likely to receive deep venous thrombosis (DVT) prophylaxis but similarly received discharge smoking cessation intervention. Inpatient mortality was also higher for those with CKD (adjusted odds ratio [OR], 1.47; 95% confidence interval [CI], 1.42-1.52), mild dysfunction (adjusted OR, 1.12; 95% CI, 1.08-1.16), moderate dysfunction (adjusted OR, 1.46; 95% CI, 1.39-1.53), severe dysfunction (adjusted OR, 1.96; 95% CI, 1.81-2.12), and kidney failure (adjusted OR, 2.22; 95% CI, 2.04-2.43) relative to those with normal renal function.

Conclusions: Chronic kidney disease is present in nearly a third of patients hospitalized with ICH and is associated with slightly worse care and substantially higher mortality than those with normal renal function.

Original languageEnglish (US)
Pages (from-to)2265-2273
Number of pages9
JournalJournal of Stroke and Cerebrovascular Diseases
Volume23
Issue number9
DOIs
StatePublished - Oct 1 2014
Externally publishedYes

Keywords

  • Chronic kidney disease
  • glomerular filtration rate
  • guidelines
  • hemorrhagic stroke
  • outcomes
  • prognosis
  • quality indicators
  • renal

ASJC Scopus subject areas

  • Surgery
  • Rehabilitation
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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