Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors

Hans D. Brightbill, Daniel H. Libraty, Stephan R. Krutzik, Ruey Bing Yang, John T. Belisle, Joshua R. Bleharski, Michael Maitland, Michael V. Norgard, Scott E. Plevy, Stephen T. Smale, Patrick J. Brennan, Barry R. Bloom, Paul J. Godowski, Robert L. Modlin

Research output: Contribution to journalArticle

1320 Scopus citations

Abstract

The generation of cell-mediated immunity against many infectious pathogens involves the production of interleukin-12 (IL-12), a key signal of the innate immune system. Yet, for many pathogens, the molecules that induce IL-12 production by macrophages and the mechanisms by which they do so remain undefined. Here it is shown that microbial lipoproteins are potent stimulators of IL-12 production by human macrophages, and that induction is mediated by Toll-like receptors (TLRs). Several lipoproteins stimulated TLR- dependent transcription of inducible nitric oxide synthase and the production of nitric oxide, a powerful microbicidal pathway. Activation of TLRs by microbial lipoproteins may initiate innate defense mechanisms against infectious pathogens.

Original languageEnglish (US)
Pages (from-to)732-736
Number of pages5
JournalScience
Volume285
Issue number5428
DOIs
StatePublished - Jul 30 1999

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors'. Together they form a unique fingerprint.

  • Cite this

    Brightbill, H. D., Libraty, D. H., Krutzik, S. R., Yang, R. B., Belisle, J. T., Bleharski, J. R., Maitland, M., Norgard, M. V., Plevy, S. E., Smale, S. T., Brennan, P. J., Bloom, B. R., Godowski, P. J., & Modlin, R. L. (1999). Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science, 285(5428), 732-736. https://doi.org/10.1126/science.285.5428.732