Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors

Hans D. Brightbill, Daniel H. Libraty, Stephan R. Krutzik, Ruey Bing Yang, John T. Belisle, Joshua R. Bleharski, Michael Maitland, Michael V. Norgard, Scott E. Plevy, Stephen T. Smale, Patrick J. Brennan, Barry R. Bloom, Paul J. Godowski, Robert L. Modlin

Research output: Contribution to journalArticle

1311 Citations (Scopus)

Abstract

The generation of cell-mediated immunity against many infectious pathogens involves the production of interleukin-12 (IL-12), a key signal of the innate immune system. Yet, for many pathogens, the molecules that induce IL-12 production by macrophages and the mechanisms by which they do so remain undefined. Here it is shown that microbial lipoproteins are potent stimulators of IL-12 production by human macrophages, and that induction is mediated by Toll-like receptors (TLRs). Several lipoproteins stimulated TLR- dependent transcription of inducible nitric oxide synthase and the production of nitric oxide, a powerful microbicidal pathway. Activation of TLRs by microbial lipoproteins may initiate innate defense mechanisms against infectious pathogens.

Original languageEnglish (US)
Pages (from-to)732-736
Number of pages5
JournalScience
Volume285
Issue number5428
DOIs
StatePublished - Jul 30 1999

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Toll-Like Receptors
Interleukin-12
Lipoproteins
Macrophages
Nitric Oxide Synthase Type II
Cellular Immunity
Immune System
Nitric Oxide

ASJC Scopus subject areas

  • General

Cite this

Brightbill, H. D., Libraty, D. H., Krutzik, S. R., Yang, R. B., Belisle, J. T., Bleharski, J. R., ... Modlin, R. L. (1999). Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science, 285(5428), 732-736. https://doi.org/10.1126/science.285.5428.732

Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. / Brightbill, Hans D.; Libraty, Daniel H.; Krutzik, Stephan R.; Yang, Ruey Bing; Belisle, John T.; Bleharski, Joshua R.; Maitland, Michael; Norgard, Michael V.; Plevy, Scott E.; Smale, Stephen T.; Brennan, Patrick J.; Bloom, Barry R.; Godowski, Paul J.; Modlin, Robert L.

In: Science, Vol. 285, No. 5428, 30.07.1999, p. 732-736.

Research output: Contribution to journalArticle

Brightbill, HD, Libraty, DH, Krutzik, SR, Yang, RB, Belisle, JT, Bleharski, JR, Maitland, M, Norgard, MV, Plevy, SE, Smale, ST, Brennan, PJ, Bloom, BR, Godowski, PJ & Modlin, RL 1999, 'Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors', Science, vol. 285, no. 5428, pp. 732-736. https://doi.org/10.1126/science.285.5428.732
Brightbill HD, Libraty DH, Krutzik SR, Yang RB, Belisle JT, Bleharski JR et al. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science. 1999 Jul 30;285(5428):732-736. https://doi.org/10.1126/science.285.5428.732
Brightbill, Hans D. ; Libraty, Daniel H. ; Krutzik, Stephan R. ; Yang, Ruey Bing ; Belisle, John T. ; Bleharski, Joshua R. ; Maitland, Michael ; Norgard, Michael V. ; Plevy, Scott E. ; Smale, Stephen T. ; Brennan, Patrick J. ; Bloom, Barry R. ; Godowski, Paul J. ; Modlin, Robert L. / Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. In: Science. 1999 ; Vol. 285, No. 5428. pp. 732-736.
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