Host-microbe interaction systems biology: Lifecycle transcriptomics and comparative genomics

Daniel E. Sturdevant, Kimmo Virtaneva, Craig Martens, Daniel Bozinov, Olajumoke Ogundare, Nina Castro, Kishore Kanakabandi, Paul A. Beare, Anders Omsland, John H. Carlson, Adam D. Kennedy, Robert A. Heinzen, Jean Celli, David E. Greenberg, Frank R. Deleo, Stephen F. Porcella

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

The use of microarray and comparative genomic technologies for the analysis of host-pathogen interactions has led to a greater understanding of the biological systems involved in infectious disease processes. Transcriptome analysis of intracellular pathogens at single or multiple time points during infection offers insight into the pathogen intracellular lifecycle. Host-pathogen transcriptome analysis in vivo, over time, enables characterization of both the pathogen and the host during the dynamic, multicellular host response. Comparative genomics using hybridization microarray-based comparative whole-genome resequencing or de novo whole-genome sequencing can identify the genetic factors responsible for pathogen evolutionary divergence, emergence, reemergence or the genetic basis for different pathogenic phenotypes. Together, microarray and comparative genomic technologies will continue to advance our understanding of pathogen evolution and assist in combating human infectious disease.

Original languageEnglish (US)
Pages (from-to)205-219
Number of pages15
JournalFuture Microbiology
Volume5
Issue number2
DOIs
StatePublished - Feb 1 2010

Keywords

  • Genomics
  • Host
  • Microarray
  • Microbe

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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    Sturdevant, D. E., Virtaneva, K., Martens, C., Bozinov, D., Ogundare, O., Castro, N., Kanakabandi, K., Beare, P. A., Omsland, A., Carlson, J. H., Kennedy, A. D., Heinzen, R. A., Celli, J., Greenberg, D. E., Deleo, F. R., & Porcella, S. F. (2010). Host-microbe interaction systems biology: Lifecycle transcriptomics and comparative genomics. Future Microbiology, 5(2), 205-219. https://doi.org/10.2217/fmb.09.125