Host-specific HCV evolution and response to the combined interferon and ribavirin therapy

James Lara; John E. Tavis; Maureen J. Donlin; William M. Lee; He Jun Yuan; Brian L. Pearlman; Gilberto Vaughan; Joseph C. Forbi; Guo Liang Xia; Yury E. Khudyakov

doi:10.1109/BIBMW.2011.6112361

Host-specific HCV evolution and response to the combined interferon and ribavirin therapy

James Lara, John E. Tavis, Maureen J. Donlin, William M. Lee, He Jun Yuan, Brian L. Pearlman, Gilberto Vaughan, Joseph C. Forbi, Guo Liang Xia, Yury E. Khudyakov

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Abstract

Machine-learning methods in the form of Bayesian networks (BN), linear projection (LP) and self-organizing tree (SOT) models were used to explore association among polymorphic sites within the HVR1 and NS5a regions of the HCV genome, host demographic factors (ethnicity, gender and age) and response to the combined interferon (IFN) and ribavirin (RBV) therapy. The BN models predicted therapy outcomes, gender and ethnicity with accuracy of 90%, 90% and 88.9%, respectively. The LP and SOT models strongly confirmed associations of the HVR1 and NS5A structures with response to therapy and demographic host factors identified by BN. The data indicate host specificity of HCV evolution and suggest the application of these models to predict outcomes of IFN/RBV therapy.

Original language	English (US)
Title of host publication	2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011
Pages	102-109
Number of pages	8
DOIs	https://doi.org/10.1109/BIBMW.2011.6112361
State	Published - 2011
Event	2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011 - Atlanta, GA, United States Duration: Nov 12 2011 → Nov 15 2011

Publication series

Name	2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011

Other

Other	2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011
Country/Territory	United States
City	Atlanta, GA
Period	11/12/11 → 11/15/11

ASJC Scopus subject areas

Biomedical Engineering
Health Informatics
Health Information Management

Access to Document

10.1109/BIBMW.2011.6112361

Cite this

Lara, J., Tavis, J. E., Donlin, M. J., Lee, W. M., Yuan, H. J., Pearlman, B. L., Vaughan, G., Forbi, J. C., Xia, G. L., & Khudyakov, Y. E. (2011). Host-specific HCV evolution and response to the combined interferon and ribavirin therapy. In 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011 (pp. 102-109). Article 6112361 (2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011). https://doi.org/10.1109/BIBMW.2011.6112361

Host-specific HCV evolution and response to the combined interferon and ribavirin therapy. / Lara, James; Tavis, John E.; Donlin, Maureen J. et al.
2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011. 2011. p. 102-109 6112361 (2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Lara, J, Tavis, JE, Donlin, MJ, Lee, WM, Yuan, HJ, Pearlman, BL, Vaughan, G, Forbi, JC, Xia, GL & Khudyakov, YE 2011, Host-specific HCV evolution and response to the combined interferon and ribavirin therapy. in 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011., 6112361, 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011, pp. 102-109, 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011, Atlanta, GA, United States, 11/12/11. https://doi.org/10.1109/BIBMW.2011.6112361

Lara J, Tavis JE, Donlin MJ, Lee WM, Yuan HJ, Pearlman BL et al. Host-specific HCV evolution and response to the combined interferon and ribavirin therapy. In 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011. 2011. p. 102-109. 6112361. (2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011). doi: 10.1109/BIBMW.2011.6112361

@inproceedings{64570650b59d48b791fab35446c6fe7b,

title = "Host-specific HCV evolution and response to the combined interferon and ribavirin therapy",

abstract = "Machine-learning methods in the form of Bayesian networks (BN), linear projection (LP) and self-organizing tree (SOT) models were used to explore association among polymorphic sites within the HVR1 and NS5a regions of the HCV genome, host demographic factors (ethnicity, gender and age) and response to the combined interferon (IFN) and ribavirin (RBV) therapy. The BN models predicted therapy outcomes, gender and ethnicity with accuracy of 90%, 90% and 88.9%, respectively. The LP and SOT models strongly confirmed associations of the HVR1 and NS5A structures with response to therapy and demographic host factors identified by BN. The data indicate host specificity of HCV evolution and suggest the application of these models to predict outcomes of IFN/RBV therapy.",

author = "James Lara and Tavis, {John E.} and Donlin, {Maureen J.} and Lee, {William M.} and Yuan, {He Jun} and Pearlman, {Brian L.} and Gilberto Vaughan and Forbi, {Joseph C.} and Xia, {Guo Liang} and Khudyakov, {Yury E.}",

note = "Copyright: Copyright 2012 Elsevier B.V., All rights reserved.; 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011 ; Conference date: 12-11-2011 Through 15-11-2011",

year = "2011",

doi = "10.1109/BIBMW.2011.6112361",

language = "English (US)",

isbn = "9781457716133",

series = "2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011",

pages = "102--109",

booktitle = "2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011",

}

TY - GEN

T1 - Host-specific HCV evolution and response to the combined interferon and ribavirin therapy

AU - Lara, James

AU - Tavis, John E.

AU - Donlin, Maureen J.

AU - Lee, William M.

AU - Yuan, He Jun

AU - Pearlman, Brian L.

AU - Vaughan, Gilberto

AU - Forbi, Joseph C.

AU - Xia, Guo Liang

AU - Khudyakov, Yury E.

PY - 2011

Y1 - 2011

N2 - Machine-learning methods in the form of Bayesian networks (BN), linear projection (LP) and self-organizing tree (SOT) models were used to explore association among polymorphic sites within the HVR1 and NS5a regions of the HCV genome, host demographic factors (ethnicity, gender and age) and response to the combined interferon (IFN) and ribavirin (RBV) therapy. The BN models predicted therapy outcomes, gender and ethnicity with accuracy of 90%, 90% and 88.9%, respectively. The LP and SOT models strongly confirmed associations of the HVR1 and NS5A structures with response to therapy and demographic host factors identified by BN. The data indicate host specificity of HCV evolution and suggest the application of these models to predict outcomes of IFN/RBV therapy.

AB - Machine-learning methods in the form of Bayesian networks (BN), linear projection (LP) and self-organizing tree (SOT) models were used to explore association among polymorphic sites within the HVR1 and NS5a regions of the HCV genome, host demographic factors (ethnicity, gender and age) and response to the combined interferon (IFN) and ribavirin (RBV) therapy. The BN models predicted therapy outcomes, gender and ethnicity with accuracy of 90%, 90% and 88.9%, respectively. The LP and SOT models strongly confirmed associations of the HVR1 and NS5A structures with response to therapy and demographic host factors identified by BN. The data indicate host specificity of HCV evolution and suggest the application of these models to predict outcomes of IFN/RBV therapy.

UR - http://www.scopus.com/inward/record.url?scp=84862917864&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862917864&partnerID=8YFLogxK

U2 - 10.1109/BIBMW.2011.6112361

DO - 10.1109/BIBMW.2011.6112361

M3 - Conference contribution

AN - SCOPUS:84862917864

SN - 9781457716133

T3 - 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011

SP - 102

EP - 109

BT - 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011

T2 - 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011

Y2 - 12 November 2011 through 15 November 2011

ER -

Host-specific HCV evolution and response to the combined interferon and ribavirin therapy

Abstract

Publication series

Other

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this