Hotspots of homologous recombination in mammalian genomes

Michael Steinmetz; Yasushi Uematsu; Kirsten Fischer Lindahl

doi:10.1016/0168-9525(87)90154-5

Hotspots of homologous recombination in mammalian genomes

Michael Steinmetz, Yasushi Uematsu, Kirsten Fischer Lindahl

Immunology

Research output: Contribution to journal › Article › peer-review

93 Scopus citations

Abstract

The mouse major histocompatibility complex (MHC) offers a unique opportunity for investigating whether homologous meiotic recombination happens at random or at specific sites. Many recombinants have been characterized and saved because of their usefulness in immunological research, and the molecular cloning of the MHC has made it possible to map the crossover points molecularly. Confinement of most of the crossover points to small regions of DNA indicates the specific sequences are involved in homologous meiotic recombination.

Original language	English (US)
Pages (from-to)	7-10
Number of pages	4
Journal	Trends in Genetics
Volume	3
Issue number	C
DOIs	https://doi.org/10.1016/0168-9525(87)90154-5
State	Published - 1987

ASJC Scopus subject areas

Genetics

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10.1016/0168-9525(87)90154-5

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title = "Hotspots of homologous recombination in mammalian genomes",

abstract = "The mouse major histocompatibility complex (MHC) offers a unique opportunity for investigating whether homologous meiotic recombination happens at random or at specific sites. Many recombinants have been characterized and saved because of their usefulness in immunological research, and the molecular cloning of the MHC has made it possible to map the crossover points molecularly. Confinement of most of the crossover points to small regions of DNA indicates the specific sequences are involved in homologous meiotic recombination.",

author = "Michael Steinmetz and Yasushi Uematsu and Lindahl, {Kirsten Fischer}",

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AB - The mouse major histocompatibility complex (MHC) offers a unique opportunity for investigating whether homologous meiotic recombination happens at random or at specific sites. Many recombinants have been characterized and saved because of their usefulness in immunological research, and the molecular cloning of the MHC has made it possible to map the crossover points molecularly. Confinement of most of the crossover points to small regions of DNA indicates the specific sequences are involved in homologous meiotic recombination.

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Hotspots of homologous recombination in mammalian genomes

Abstract

ASJC Scopus subject areas

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