How are specialized (low-fidelity) eukaryotic polymerases selected and switched with high-fidelity polymerases during translesion DNA synthesis?

Paula L. Fischhaber, Errol C. Friedberg

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Specialized DNA polymerases are required in both prokaryotic and eukaryotic cells for bypassing sites of template DNA damage that arrest high-fidelity DNA replication. Recent studies in the literature provide hints of the complexity of DNA switching between polymerases for translesion DNA synthesis (TLS) and those for normal DNA replication.

Original languageEnglish (US)
Pages (from-to)279-283
Number of pages5
JournalDNA Repair
Volume4
Issue number2
DOIs
Publication statusPublished - Feb 3 2005

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Keywords

  • Eta
  • Iota
  • Kappa
  • Low-fidelity
  • PCNA
  • Polymerase switching
  • Post-translational modification
  • SUMO
  • TLS
  • Ubiquitin
  • Xeroderma pigmentosum
  • XPV
  • Y-family
  • Zeta

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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