How are specialized (low-fidelity) eukaryotic polymerases selected and switched with high-fidelity polymerases during translesion DNA synthesis?

Paula L. Fischhaber; Errol C. Friedberg

doi:10.1016/j.dnarep.2004.08.011

How are specialized (low-fidelity) eukaryotic polymerases selected and switched with high-fidelity polymerases during translesion DNA synthesis?

Paula L. Fischhaber, Errol C. Friedberg

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Specialized DNA polymerases are required in both prokaryotic and eukaryotic cells for bypassing sites of template DNA damage that arrest high-fidelity DNA replication. Recent studies in the literature provide hints of the complexity of DNA switching between polymerases for translesion DNA synthesis (TLS) and those for normal DNA replication.

Original language	English (US)
Pages (from-to)	279-283
Number of pages	5
Journal	DNA repair
Volume	4
Issue number	2
DOIs	https://doi.org/10.1016/j.dnarep.2004.08.011
State	Published - Feb 3 2005

Keywords

Eta
Iota
Kappa
Low-fidelity
PCNA
Polymerase switching
Post-translational modification
SUMO
TLS
Ubiquitin
XPV
Xeroderma pigmentosum
Y-family
Zeta

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1016/j.dnarep.2004.08.011

Cite this

@article{2103333bbfda49d89bac307fac455db2,

title = "How are specialized (low-fidelity) eukaryotic polymerases selected and switched with high-fidelity polymerases during translesion DNA synthesis?",

abstract = "Specialized DNA polymerases are required in both prokaryotic and eukaryotic cells for bypassing sites of template DNA damage that arrest high-fidelity DNA replication. Recent studies in the literature provide hints of the complexity of DNA switching between polymerases for translesion DNA synthesis (TLS) and those for normal DNA replication.",

keywords = "Eta, Iota, Kappa, Low-fidelity, PCNA, Polymerase switching, Post-translational modification, SUMO, TLS, Ubiquitin, XPV, Xeroderma pigmentosum, Y-family, Zeta",

author = "Fischhaber, {Paula L.} and Friedberg, {Errol C.}",

year = "2005",

month = feb,

day = "3",

doi = "10.1016/j.dnarep.2004.08.011",

language = "English (US)",

volume = "4",

pages = "279--283",

journal = "DNA repair",

issn = "1568-7864",