How much can SNAREs flex their muscles?

Jose Rizo-Rey, Han Dai

Research output: Contribution to journalShort survey

4 Scopus citations

Abstract

The high stability of SNARE complexes is probably crucial for their role in membrane fusion, but it has been difficult to measure. A surface-forces apparatus has now been used to measure the stabilization energy of a partially assembled SNARE complex, and the result (35 kBT) is among the highest protein-folding free energies ever observed. Moreover, this approach offers a bright future for further structural and energetic studies of membrane fusion machineries.

Original languageEnglish (US)
Pages (from-to)880-882
Number of pages3
JournalNature Structural and Molecular Biology
Volume14
Issue number10
DOIs
StatePublished - Oct 1 2007

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

Fingerprint Dive into the research topics of 'How much can SNAREs flex their muscles?'. Together they form a unique fingerprint.

  • Cite this