TY - JOUR
T1 - How much can SNAREs flex their muscles?
AU - Rizo-Rey, Jose
AU - Dai, Han
PY - 2007/10
Y1 - 2007/10
N2 - The high stability of SNARE complexes is probably crucial for their role in membrane fusion, but it has been difficult to measure. A surface-forces apparatus has now been used to measure the stabilization energy of a partially assembled SNARE complex, and the result (35 kBT) is among the highest protein-folding free energies ever observed. Moreover, this approach offers a bright future for further structural and energetic studies of membrane fusion machineries.
AB - The high stability of SNARE complexes is probably crucial for their role in membrane fusion, but it has been difficult to measure. A surface-forces apparatus has now been used to measure the stabilization energy of a partially assembled SNARE complex, and the result (35 kBT) is among the highest protein-folding free energies ever observed. Moreover, this approach offers a bright future for further structural and energetic studies of membrane fusion machineries.
UR - http://www.scopus.com/inward/record.url?scp=34948885198&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34948885198&partnerID=8YFLogxK
U2 - 10.1038/nsmb1007-880
DO - 10.1038/nsmb1007-880
M3 - Short survey
C2 - 17912256
AN - SCOPUS:34948885198
SN - 1545-9993
VL - 14
SP - 880
EP - 882
JO - Nature Structural and Molecular Biology
JF - Nature Structural and Molecular Biology
IS - 10
ER -