How nucleotide excision repair protects against cancer

Errol C. Friedberg

doi:10.1038/35094000

How nucleotide excision repair protects against cancer

Errol C. Friedberg

Research output: Contribution to journal › Article › peer-review

591 Scopus citations

Abstract

Eukaryotic cells can repair many types of DNA damage. Among the known DNA repair processes in humans, one type - nucleotide excision repair (NER) - specifically protects against mutations caused indirectly by environmental carcinogens. Humans with a hereditary defect in NER suffer from xeroderma pigmentosum and have a marked predisposition to skin cancer caused by sunlight exposure. How does NER protect against skin cancer and possibly other types of environmentally induced cancer in humans?

Original language	English (US)
Pages (from-to)	22-33
Number of pages	12
Journal	Nature Reviews Cancer
Volume	1
Issue number	1
DOIs	https://doi.org/10.1038/35094000
State	Published - Jan 1 2001

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1038/35094000

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abstract = "Eukaryotic cells can repair many types of DNA damage. Among the known DNA repair processes in humans, one type - nucleotide excision repair (NER) - specifically protects against mutations caused indirectly by environmental carcinogens. Humans with a hereditary defect in NER suffer from xeroderma pigmentosum and have a marked predisposition to skin cancer caused by sunlight exposure. How does NER protect against skin cancer and possibly other types of environmentally induced cancer in humans?",

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How nucleotide excision repair protects against cancer

Abstract

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