Abstract
Eukaryotic cells can repair many types of DNA damage. Among the known DNA repair processes in humans, one type - nucleotide excision repair (NER) - specifically protects against mutations caused indirectly by environmental carcinogens. Humans with a hereditary defect in NER suffer from xeroderma pigmentosum and have a marked predisposition to skin cancer caused by sunlight exposure. How does NER protect against skin cancer and possibly other types of environmentally induced cancer in humans?
| Original language | English (US) |
|---|---|
| Pages (from-to) | 22-33 |
| Number of pages | 12 |
| Journal | Nature Reviews Cancer |
| Volume | 1 |
| Issue number | 1 |
| State | Published - 2001 |
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ASJC Scopus subject areas
- Cancer Research
Cite this
How nucleotide excision repair protects against cancer. / Friedberg, Errol C.
In: Nature Reviews Cancer, Vol. 1, No. 1, 2001, p. 22-33.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - How nucleotide excision repair protects against cancer
AU - Friedberg, Errol C.
PY - 2001
Y1 - 2001
N2 - Eukaryotic cells can repair many types of DNA damage. Among the known DNA repair processes in humans, one type - nucleotide excision repair (NER) - specifically protects against mutations caused indirectly by environmental carcinogens. Humans with a hereditary defect in NER suffer from xeroderma pigmentosum and have a marked predisposition to skin cancer caused by sunlight exposure. How does NER protect against skin cancer and possibly other types of environmentally induced cancer in humans?
AB - Eukaryotic cells can repair many types of DNA damage. Among the known DNA repair processes in humans, one type - nucleotide excision repair (NER) - specifically protects against mutations caused indirectly by environmental carcinogens. Humans with a hereditary defect in NER suffer from xeroderma pigmentosum and have a marked predisposition to skin cancer caused by sunlight exposure. How does NER protect against skin cancer and possibly other types of environmentally induced cancer in humans?
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UR - http://www.scopus.com/inward/citedby.url?scp=0035495386&partnerID=8YFLogxK
M3 - Article
C2 - 11900249
AN - SCOPUS:0035495386
VL - 1
SP - 22
EP - 33
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
SN - 1474-175X
IS - 1
ER -