How nucleotide excision repair protects against cancer

Errol C. Friedberg

doi:10.1038/35094000

How nucleotide excision repair protects against cancer

Errol C. Friedberg

Research output: Contribution to journal › Article › peer-review

604 Scopus citations

Abstract

Eukaryotic cells can repair many types of DNA damage. Among the known DNA repair processes in humans, one type - nucleotide excision repair (NER) - specifically protects against mutations caused indirectly by environmental carcinogens. Humans with a hereditary defect in NER suffer from xeroderma pigmentosum and have a marked predisposition to skin cancer caused by sunlight exposure. How does NER protect against skin cancer and possibly other types of environmentally induced cancer in humans?

Original language	English (US)
Pages (from-to)	22-33
Number of pages	12
Journal	Nature Reviews Cancer
Volume	1
Issue number	1
DOIs	https://doi.org/10.1038/35094000
State	Published - Jan 1 2001

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1038/35094000

Cite this

@article{ed8abfdc22504f499e938dcc746535ac,

title = "How nucleotide excision repair protects against cancer",

abstract = "Eukaryotic cells can repair many types of DNA damage. Among the known DNA repair processes in humans, one type - nucleotide excision repair (NER) - specifically protects against mutations caused indirectly by environmental carcinogens. Humans with a hereditary defect in NER suffer from xeroderma pigmentosum and have a marked predisposition to skin cancer caused by sunlight exposure. How does NER protect against skin cancer and possibly other types of environmentally induced cancer in humans?",

author = "Friedberg, {Errol C.}",

year = "2001",

month = jan,

day = "1",

doi = "10.1038/35094000",

language = "English (US)",

volume = "1",

pages = "22--33",

journal = "Nature Reviews Cancer",

issn = "1474-175X",

publisher = "Nature Publishing Group",

number = "1",

}

TY - JOUR

T1 - How nucleotide excision repair protects against cancer

AU - Friedberg, Errol C.

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Eukaryotic cells can repair many types of DNA damage. Among the known DNA repair processes in humans, one type - nucleotide excision repair (NER) - specifically protects against mutations caused indirectly by environmental carcinogens. Humans with a hereditary defect in NER suffer from xeroderma pigmentosum and have a marked predisposition to skin cancer caused by sunlight exposure. How does NER protect against skin cancer and possibly other types of environmentally induced cancer in humans?

AB - Eukaryotic cells can repair many types of DNA damage. Among the known DNA repair processes in humans, one type - nucleotide excision repair (NER) - specifically protects against mutations caused indirectly by environmental carcinogens. Humans with a hereditary defect in NER suffer from xeroderma pigmentosum and have a marked predisposition to skin cancer caused by sunlight exposure. How does NER protect against skin cancer and possibly other types of environmentally induced cancer in humans?

UR - http://www.scopus.com/inward/record.url?scp=0035495386&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035495386&partnerID=8YFLogxK

U2 - 10.1038/35094000

DO - 10.1038/35094000

M3 - Article

C2 - 11900249

AN - SCOPUS:0035495386

SN - 1474-175X

VL - 1

SP - 22

EP - 33

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

IS - 1

ER -

How nucleotide excision repair protects against cancer

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this