How nucleotide excision repair protects against cancer

Research output: Contribution to journalArticle

546 Scopus citations

Abstract

Eukaryotic cells can repair many types of DNA damage. Among the known DNA repair processes in humans, one type - nucleotide excision repair (NER) - specifically protects against mutations caused indirectly by environmental carcinogens. Humans with a hereditary defect in NER suffer from xeroderma pigmentosum and have a marked predisposition to skin cancer caused by sunlight exposure. How does NER protect against skin cancer and possibly other types of environmentally induced cancer in humans?

Original languageEnglish (US)
Pages (from-to)22-33
Number of pages12
JournalNature Reviews Cancer
Volume1
Issue number1
DOIs
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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