How nucleotide excision repair protects against cancer

Research output: Contribution to journalArticle

530 Citations (Scopus)

Abstract

Eukaryotic cells can repair many types of DNA damage. Among the known DNA repair processes in humans, one type - nucleotide excision repair (NER) - specifically protects against mutations caused indirectly by environmental carcinogens. Humans with a hereditary defect in NER suffer from xeroderma pigmentosum and have a marked predisposition to skin cancer caused by sunlight exposure. How does NER protect against skin cancer and possibly other types of environmentally induced cancer in humans?

Original languageEnglish (US)
Pages (from-to)22-33
Number of pages12
JournalNature Reviews Cancer
Volume1
Issue number1
StatePublished - 2001

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DNA Repair
Skin Neoplasms
Neoplasms
Environmental Carcinogens
Xeroderma Pigmentosum
Sunlight
Eukaryotic Cells
DNA Damage
Mutation

ASJC Scopus subject areas

  • Cancer Research

Cite this

How nucleotide excision repair protects against cancer. / Friedberg, Errol C.

In: Nature Reviews Cancer, Vol. 1, No. 1, 2001, p. 22-33.

Research output: Contribution to journalArticle

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