TY - JOUR
T1 - How obesity causes diabetes in Zucker diabetic fatty rats
AU - Unger, Roger H
PY - 1997/9
Y1 - 1997/9
N2 - The mechanisms of adipogenic diabetes in Zucker diabetic fatty (ZDF) rats, a model of obesity complicated by diabetes, are reviewed. In ZDF rats, a mutation in the leptin receptor, OB-R, is associated with leptin resistance, obesity, and increased fat content of islets. Exaggerated nitric oxide (NO) generation, attributed to high intracellular levels of long-chain fatty acids, impairs β-cell function and prevents their compensation for obesity-induced diabetes. The resulting diabetic hyperglycemia can be completely prevented by agents that inhibit NO production.
AB - The mechanisms of adipogenic diabetes in Zucker diabetic fatty (ZDF) rats, a model of obesity complicated by diabetes, are reviewed. In ZDF rats, a mutation in the leptin receptor, OB-R, is associated with leptin resistance, obesity, and increased fat content of islets. Exaggerated nitric oxide (NO) generation, attributed to high intracellular levels of long-chain fatty acids, impairs β-cell function and prevents their compensation for obesity-induced diabetes. The resulting diabetic hyperglycemia can be completely prevented by agents that inhibit NO production.
UR - http://www.scopus.com/inward/record.url?scp=0031239663&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031239663&partnerID=8YFLogxK
U2 - 10.1016/S1043-2760(97)00094-5
DO - 10.1016/S1043-2760(97)00094-5
M3 - Review article
C2 - 18406816
AN - SCOPUS:0031239663
SN - 1043-2760
VL - 8
SP - 276
EP - 282
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 7
ER -