How temperature changes reset a circadian oscillator

Yi Liu, Martha Merrow, Jennifer J. Loros, Jay C. Dunlap

Research output: Contribution to journalArticlepeer-review

174 Scopus citations

Abstract

Circadian rhythms control many physiological activities. The environmental entrainment of rhythms involves the immediate responses of clock components. Levels of the clock protein FRQ were measured in Neurospora at various temperatures; at higher temperatures, the amount of FRQ oscillated around higher levels. Absolute FRQ amounts thus identified different times at different temperatures, so temperature shifts corresponded to shifts in clock time without immediate synthesis or turnover of components. Moderate temperature changes could dominate light-to-dark shifts in the influence of circadian timing. Temperature regulation of clock components could explain temperature resetting of rhythms and how single transitions can initiate rhythmicity from characteristic circadian phases.

Original languageEnglish (US)
Pages (from-to)825-829
Number of pages5
JournalScience
Volume281
Issue number5378
DOIs
StatePublished - Aug 7 1998

ASJC Scopus subject areas

  • General

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