HPV-related oropharyngeal cancer: Risk factors for treatment failure in patients managed with primary transoral robotic surgery

John M. Kaczmar, Kay See Tan, Daniel F. Heitjan, Alexander Lin, Peter H. Ahn, Jason G. Newman, Christopher H. Rassekh, Ara A. Chalian, Bert W. O'Malley, Roger B. Cohen, Gregory S. Weinstein

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Background The purpose of this study was to determine clinical factors that predict locoregional recurrence or distant metastasis in patients with human papillomavirus (HPV)-positive oropharyngeal cancer treated with surgery and guideline-indicated adjuvant therapy. Methods We identified all presumed HPV-positive patients with oropharyngeal cancer in our health system from January 2010 to August 2012 treated with surgery and guideline-indicated adjuvant therapy. Statistical analysis was performed to identify clinical predictors associated with treatment failure. Results One hundred fourteen p16+ oropharyngeal cancers managed with initial surgical resection were identified. Median follow-up was 17 months. Two-year locoregional failure was 3.3% and distant failure was 8.4%. Statistical analysis found that conventional poor prognostic features did not predict treatment failure. Conclusion Locoregional recurrence and development of distant metastatic disease are uncommon in patients who are appropriately selected for surgical management of p16+ oropharyngeal cancer regardless of the presence or absence of conventional poor prognostic features.

Original languageEnglish (US)
Pages (from-to)59-65
Number of pages7
JournalHead and Neck
Volume38
Issue number1
DOIs
StatePublished - Jan 1 2016

Keywords

  • human papillomavirus (HPV)
  • oropharyngeal
  • p16
  • prognostic factors
  • transoral robotic surgery (TORS)

ASJC Scopus subject areas

  • Otorhinolaryngology

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    Kaczmar, J. M., Tan, K. S., Heitjan, D. F., Lin, A., Ahn, P. H., Newman, J. G., Rassekh, C. H., Chalian, A. A., O'Malley, B. W., Cohen, R. B., & Weinstein, G. S. (2016). HPV-related oropharyngeal cancer: Risk factors for treatment failure in patients managed with primary transoral robotic surgery. Head and Neck, 38(1), 59-65. https://doi.org/10.1002/hed.23850