HSP70 promotes MLKL polymerization and necroptosis

Andrea N. Johnston, Zhigao Wang

Research output: Contribution to journalArticle

Abstract

Mixed lineage kinase domain-like protein (MLKL) is the proposed executioner of necroptosis. Our recent findings identify a novel inhibitor necroptosis-blocking compound 1 (NBC1) which specifically conjugates to two cysteines of heat shock protein 70 (HSP70) to block its function. Importantly, HSP70 promotes MLKL polymerization to activate necroptosis.

Original languageEnglish (US)
Article number1791561
JournalMolecular and Cellular Oncology
DOIs
StatePublished - 2020

Keywords

  • regulated cell death
  • HSP70
  • MLKL
  • Necroptosis

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research

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