Human baroreflex rhythms persist during handgrip and muscle ischaemia

D. L. Eckberg, W. H. Cooke, A. Diedrich, B. D. Levine, J. A. Pawelczyk, J. C. Buckey, A. C. Ertl, I. Biaggioni, J. F. Cox, D. Robertson, F. J. Baisch, C. G. Blomqvist, T. A. Kuusela, K. U O Tahvanainen

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Aim: To determine whether physiological, rhythmic fluctuations of vagal baroreflex gain persist during exercise, post-exercise ischaemia and recovery. Methods: We studied responses of six supine healthy men and one woman to a stereotyped protocol comprising rest, handgrip exercise at 40% maximum capacity to exhaustion, post-exercise forearm ischaemia and recovery. We measured electrocardiographic R-R intervals, photoplethysmographic finger arterial pressures and peroneal nerve muscle sympathetic activity. We derived vagal baroreflex gains from a sliding (25-s window moved by 2-s steps) systolic pressure-R-R interval transfer function at 0.04-0.15 Hz. Results: Vagal baroreflex gain oscillated at low, nearly constant frequencies throughout the protocol (at approx. 0.06 Hz - a period of about 18 s); however, during exercise, most oscillations were at low-gain levels, and during ischaemia and recovery, most oscillations were at high-gain levels. Conclusions: Vagal baroreflex rhythms are not abolished by exercise, and they are not overwhelmed after exercise during ischaemia and recovery. Published 2013. This article is a U.S. Government work and is in the public domain in the U.S.A.

Original languageEnglish (US)
Pages (from-to)114-123
Number of pages10
JournalActa Physiologica
Volume209
Issue number2
DOIs
StatePublished - Oct 2013

Keywords

  • Exercise
  • Resetting
  • Sympathetic
  • Vagal

ASJC Scopus subject areas

  • Physiology

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