TY - JOUR
T1 - Human brain evolution
T2 - Harnessing the genomics (R)evolution to link genes, cognition, and behavior
AU - Konopka, Genevieve
AU - Geschwind, Daniel H.
N1 - Funding Information:
This work is supported by a grant from the NIMH (R37MH60233-06A1) to D.H.G. G.K. is supported by an A.P. Giannini Foundation Medical Research Fellowship, a NARSAD Young Investigator Award, and the NIMH (K99MH090238).
PY - 2010/10/21
Y1 - 2010/10/21
N2 - The evolution of the human brain has resulted in numerous specialized features including higher cognitive processes such as language. Knowledge of whole-genome sequence and structural variation via high-throughput sequencing technology provides an unprecedented opportunity to view human evolution at high resolution. However, phenotype discovery is a critical component of these endeavors and the use of nontraditional model organisms will also be critical for piecing together a complete picture. Ultimately, the union of developmental studies of the brain with studies of unique phenotypes in a myriad of species will result in a more thorough model of the groundwork the human brain was built upon. Furthermore, these integrative approaches should provide important insights into human diseases.
AB - The evolution of the human brain has resulted in numerous specialized features including higher cognitive processes such as language. Knowledge of whole-genome sequence and structural variation via high-throughput sequencing technology provides an unprecedented opportunity to view human evolution at high resolution. However, phenotype discovery is a critical component of these endeavors and the use of nontraditional model organisms will also be critical for piecing together a complete picture. Ultimately, the union of developmental studies of the brain with studies of unique phenotypes in a myriad of species will result in a more thorough model of the groundwork the human brain was built upon. Furthermore, these integrative approaches should provide important insights into human diseases.
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U2 - 10.1016/j.neuron.2010.10.012
DO - 10.1016/j.neuron.2010.10.012
M3 - Review article
C2 - 20955931
AN - SCOPUS:77957928404
SN - 0896-6273
VL - 68
SP - 231
EP - 244
JO - Neuron
JF - Neuron
IS - 2
ER -