Human brain evolution: Harnessing the genomics (R)evolution to link genes, cognition, and behavior

Genevieve Konopka, Daniel H. Geschwind

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

The evolution of the human brain has resulted in numerous specialized features including higher cognitive processes such as language. Knowledge of whole-genome sequence and structural variation via high-throughput sequencing technology provides an unprecedented opportunity to view human evolution at high resolution. However, phenotype discovery is a critical component of these endeavors and the use of nontraditional model organisms will also be critical for piecing together a complete picture. Ultimately, the union of developmental studies of the brain with studies of unique phenotypes in a myriad of species will result in a more thorough model of the groundwork the human brain was built upon. Furthermore, these integrative approaches should provide important insights into human diseases.

Original languageEnglish (US)
Pages (from-to)231-244
Number of pages14
JournalNeuron
Volume68
Issue number2
DOIs
Publication statusPublished - Oct 21 2010

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ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

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