Human brain white matter atlas: Identification and assignment of common anatomical structures in superficial white matter

Kenichi Oishi, Karl Zilles, Katrin Amunts, Andreia Faria, Hangyi Jiang, Xin Li, Kazi Akhter, Kegang Hua, Roger Woods, Arthur W. Toga, G. Bruce Pike, Pedro Rosa-Neto, Alan Evans, Jiangyang Zhang, Hao Huang, Michael I. Miller, Peter C M van Zijl, John Mazziotta, Susumu Mori

Research output: Contribution to journalArticlepeer-review

312 Scopus citations

Abstract

Structural delineation and assignment are the fundamental steps in understanding the anatomy of the human brain. The white matter has been structurally defined in the past only at its core regions (deep white matter). However, the most peripheral white matter areas, which are interleaved between the cortex and the deep white matter, have lacked clear anatomical definitions and parcellations. We used axonal fiber alignment information from diffusion tensor imaging (DTI) to delineate the peripheral white matter, and investigated its relationship with the cortex and the deep white matter. Using DTI data from 81 healthy subjects, we identified nine common, blade-like anatomical regions, which were further parcellated into 21 subregions based on the cortical anatomy. Four short association fiber tracts connecting adjacent gyri (U-fibers) were also identified reproducibly among the healthy population. We anticipate that this atlas will be useful resource for atlas-based white matter anatomical studies.

Original languageEnglish (US)
Pages (from-to)447-457
Number of pages11
JournalNeuroImage
Volume43
Issue number3
DOIs
StatePublished - Nov 15 2008

Keywords

  • Association fiber
  • Atlas
  • Diffusion tensor
  • Human
  • Magnetic resonance imaging
  • White matter

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

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