Human breast lesions

Characterization with proton MR spectroscopy

Joseph R. Roebuck, Kim M. Cecil, Mitchell D. Schnall, Robert E. Lenkinski

Research output: Contribution to journalArticle

206 Citations (Scopus)

Abstract

PURPOSE: To assess the clinical usefulness of spatially localized hydrogen-1 magnetic resonance (MR) spectroscopy in distinguishing benign from malignant lesions on the basis of total choline levels. MATERIALS AND METHODS: These studies were performed at 1.5 T with a four-channel multicoil that compresses the breast sagittally. Contrast material enhanced MR imaging and single-voxel H-1 MR spectroscopy were performed in 17 patients (age range, 25-68 years) who had nonspecific mammographic findings. Histopathologic correlations were made from biopsy or surgical specimens. Ten patients had various malignant breast lesions 1-4 cm in diameter, and seven patients had benign processes. RESULTS: Most studies were performed with nominal voxel sizes (<2 cm3). Spectra obtained with an echo time of 31 msec showed resonances from water and mobile fatty acids and, in some cases, the N-trimethyl resonance of choline-containing compounds (Cho) at 3.2 ppm. The absolute concentration of Cho in each lesion was determined with a phantom containing 1 mmol/L Cho as an external reference. On the basis of reference measurements, the least detectable level of Cho was 0.2 mmol/L. With this threshold, seven of 10 malignant lesions showed detectable levels of Cho. In contrast, Cho was seen in only one patient with an extremely rare benign process, a tubular adenoma. The remaining six patients with benign processes demonstrated no detectable Cho levels. CONCLUSION: Spatially localized H-1 MR spectroscopy can provide sufficient sensitivity and spectral resolution at 1.5 T to demonstrate Cho in human breast lesions with a spectroscopic protocol that provides up to 1-cm3 resolution. Determining the presence of Cho may provide a useful test for malignancy.

Original languageEnglish (US)
Pages (from-to)269-275
Number of pages7
JournalRadiology
Volume209
Issue number1
StatePublished - Oct 1998

Fingerprint

Breast
Magnetic Resonance Spectroscopy
Choline
Adenoma
Contrast Media
Hydrogen
Fatty Acids
Magnetic Resonance Imaging
Proton Magnetic Resonance Spectroscopy
Biopsy
Water
Neoplasms

Keywords

  • Breast neoplasms, diagnosis
  • Breast neoplasms, MR
  • Magnetic resonance (MR), spectroscopy

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Roebuck, J. R., Cecil, K. M., Schnall, M. D., & Lenkinski, R. E. (1998). Human breast lesions: Characterization with proton MR spectroscopy. Radiology, 209(1), 269-275.

Human breast lesions : Characterization with proton MR spectroscopy. / Roebuck, Joseph R.; Cecil, Kim M.; Schnall, Mitchell D.; Lenkinski, Robert E.

In: Radiology, Vol. 209, No. 1, 10.1998, p. 269-275.

Research output: Contribution to journalArticle

Roebuck, JR, Cecil, KM, Schnall, MD & Lenkinski, RE 1998, 'Human breast lesions: Characterization with proton MR spectroscopy', Radiology, vol. 209, no. 1, pp. 269-275.
Roebuck JR, Cecil KM, Schnall MD, Lenkinski RE. Human breast lesions: Characterization with proton MR spectroscopy. Radiology. 1998 Oct;209(1):269-275.
Roebuck, Joseph R. ; Cecil, Kim M. ; Schnall, Mitchell D. ; Lenkinski, Robert E. / Human breast lesions : Characterization with proton MR spectroscopy. In: Radiology. 1998 ; Vol. 209, No. 1. pp. 269-275.
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