Human chromosome 7: DNA sequence and biology

Stephen W. Scherer, Joseph Cheung, Jeffrey R. MacDonald, Lucy R. Osborne, Kazuhiko Nakabayashi, Jo Anne Herbrick, Andrew R. Carson, Layla Parker-Katiraee, Jennifer Skaug, Razi Khaja, Junjun Zhang, Alexander K. Hudek, Martin Li, May Haddad, Gavin E. Duggan, Bridget A. Fernandez, Emiko Kanematsu, Simone Gentles, Constantine C. Christopoulos, Sanaa ChoufaniDorota Kwasnicka, Xiangqun H. Zheng, Zhongwu Lai, Deborah Nusskern, Qing Zhang, Zhiping Gu, Fu Lu, Susan Zeesman, Malgorzata J. Nowaczyk, Ikuko Teshima, David Chitayat, Cheryl Shuman, Rosanna Weksberg, Elaine H. Zackai, Theresa A. Grebe, Sarah R. Cox, Susan J. Kirkpatrick, Nazneen Rahman, Jan M. Friedman, Henry H.Q. Heng, Pier Giuseppe Pelicci, Francesco Lo-Coco, Elena Belloni, Lisa G. Shaffer, Barbara Pober, Cynthia C. Morton, James F. Gusella, Gail A.P. Bruns, Bruce R. Korf, Bradley J. Quade, Azra H. Ligon, Heather Ferguson, Anne W. Higgins, Natalia T. Leach, Steven R. Herrick, Emmanuelle Lemyre, Chantal G. Farra, Hyung Goo Kim, Anne M. Summers, Karen W. Gripp, Wendy Roberts, Peter Szatmari, Elizabeth J.T. Winsor, Karl Heinz Grzeschik, Ahmed Teebi, Berge A. Minassian, Juha Kere, Luis Armengol, Miguel Angel Pujana, Xavier Estivill, Michael D. Wilson, Ben F. Koop, Sabrina Tosi, Gudrun E. Moore, Andrew P. Boright, Eitan Zlotorynski, Batsheva Kerem, Peter M. Kroisel, Erwin Petek, David G. Oscier, Sarah J. Mould, Hartmut Döhner, Konstanze Döhner, Johanna M. Rommens, John B. Vincent, J. Craig Venter, Peter W. Li, Richard J. Mural, Mark D. Adams, Lap Chee Tsui

Research output: Contribution to journalArticle

152 Citations (Scopus)

Abstract

DNA sequence and annotation of the entire human chromosome 7, encompassing nearly 158 million nucleotides of DNA and 1917 gene structures, are presented. To generate a higher order description, additional structural features such as imprinted genes, fragile sites, and segmental duplications were integrated at the level of the DNA sequence with medical genetic data, including 440 chromosome rearrangement breakpoints associated with disease. This approach enabled the discovery of candidate genes for developmental diseases including autism.

Original languageEnglish (US)
Pages (from-to)767-772
Number of pages6
JournalScience
Volume300
Issue number5620
DOIs
StatePublished - May 2 2003

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Chromosomes, Human, Pair 7
Human Chromosomes
Chromosome Breakpoints
Genomic Segmental Duplications
Developmental Genes
Medical Genetics
Genetic Association Studies
Autistic Disorder
Genes
Nucleotides
DNA

ASJC Scopus subject areas

  • General

Cite this

Scherer, S. W., Cheung, J., MacDonald, J. R., Osborne, L. R., Nakabayashi, K., Herbrick, J. A., ... Tsui, L. C. (2003). Human chromosome 7: DNA sequence and biology. Science, 300(5620), 767-772. https://doi.org/10.1126/science.1083423

Human chromosome 7 : DNA sequence and biology. / Scherer, Stephen W.; Cheung, Joseph; MacDonald, Jeffrey R.; Osborne, Lucy R.; Nakabayashi, Kazuhiko; Herbrick, Jo Anne; Carson, Andrew R.; Parker-Katiraee, Layla; Skaug, Jennifer; Khaja, Razi; Zhang, Junjun; Hudek, Alexander K.; Li, Martin; Haddad, May; Duggan, Gavin E.; Fernandez, Bridget A.; Kanematsu, Emiko; Gentles, Simone; Christopoulos, Constantine C.; Choufani, Sanaa; Kwasnicka, Dorota; Zheng, Xiangqun H.; Lai, Zhongwu; Nusskern, Deborah; Zhang, Qing; Gu, Zhiping; Lu, Fu; Zeesman, Susan; Nowaczyk, Malgorzata J.; Teshima, Ikuko; Chitayat, David; Shuman, Cheryl; Weksberg, Rosanna; Zackai, Elaine H.; Grebe, Theresa A.; Cox, Sarah R.; Kirkpatrick, Susan J.; Rahman, Nazneen; Friedman, Jan M.; Heng, Henry H.Q.; Pelicci, Pier Giuseppe; Lo-Coco, Francesco; Belloni, Elena; Shaffer, Lisa G.; Pober, Barbara; Morton, Cynthia C.; Gusella, James F.; Bruns, Gail A.P.; Korf, Bruce R.; Quade, Bradley J.; Ligon, Azra H.; Ferguson, Heather; Higgins, Anne W.; Leach, Natalia T.; Herrick, Steven R.; Lemyre, Emmanuelle; Farra, Chantal G.; Kim, Hyung Goo; Summers, Anne M.; Gripp, Karen W.; Roberts, Wendy; Szatmari, Peter; Winsor, Elizabeth J.T.; Grzeschik, Karl Heinz; Teebi, Ahmed; Minassian, Berge A.; Kere, Juha; Armengol, Luis; Pujana, Miguel Angel; Estivill, Xavier; Wilson, Michael D.; Koop, Ben F.; Tosi, Sabrina; Moore, Gudrun E.; Boright, Andrew P.; Zlotorynski, Eitan; Kerem, Batsheva; Kroisel, Peter M.; Petek, Erwin; Oscier, David G.; Mould, Sarah J.; Döhner, Hartmut; Döhner, Konstanze; Rommens, Johanna M.; Vincent, John B.; Venter, J. Craig; Li, Peter W.; Mural, Richard J.; Adams, Mark D.; Tsui, Lap Chee.

In: Science, Vol. 300, No. 5620, 02.05.2003, p. 767-772.

Research output: Contribution to journalArticle

Scherer, SW, Cheung, J, MacDonald, JR, Osborne, LR, Nakabayashi, K, Herbrick, JA, Carson, AR, Parker-Katiraee, L, Skaug, J, Khaja, R, Zhang, J, Hudek, AK, Li, M, Haddad, M, Duggan, GE, Fernandez, BA, Kanematsu, E, Gentles, S, Christopoulos, CC, Choufani, S, Kwasnicka, D, Zheng, XH, Lai, Z, Nusskern, D, Zhang, Q, Gu, Z, Lu, F, Zeesman, S, Nowaczyk, MJ, Teshima, I, Chitayat, D, Shuman, C, Weksberg, R, Zackai, EH, Grebe, TA, Cox, SR, Kirkpatrick, SJ, Rahman, N, Friedman, JM, Heng, HHQ, Pelicci, PG, Lo-Coco, F, Belloni, E, Shaffer, LG, Pober, B, Morton, CC, Gusella, JF, Bruns, GAP, Korf, BR, Quade, BJ, Ligon, AH, Ferguson, H, Higgins, AW, Leach, NT, Herrick, SR, Lemyre, E, Farra, CG, Kim, HG, Summers, AM, Gripp, KW, Roberts, W, Szatmari, P, Winsor, EJT, Grzeschik, KH, Teebi, A, Minassian, BA, Kere, J, Armengol, L, Pujana, MA, Estivill, X, Wilson, MD, Koop, BF, Tosi, S, Moore, GE, Boright, AP, Zlotorynski, E, Kerem, B, Kroisel, PM, Petek, E, Oscier, DG, Mould, SJ, Döhner, H, Döhner, K, Rommens, JM, Vincent, JB, Venter, JC, Li, PW, Mural, RJ, Adams, MD & Tsui, LC 2003, 'Human chromosome 7: DNA sequence and biology', Science, vol. 300, no. 5620, pp. 767-772. https://doi.org/10.1126/science.1083423
Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA et al. Human chromosome 7: DNA sequence and biology. Science. 2003 May 2;300(5620):767-772. https://doi.org/10.1126/science.1083423
Scherer, Stephen W. ; Cheung, Joseph ; MacDonald, Jeffrey R. ; Osborne, Lucy R. ; Nakabayashi, Kazuhiko ; Herbrick, Jo Anne ; Carson, Andrew R. ; Parker-Katiraee, Layla ; Skaug, Jennifer ; Khaja, Razi ; Zhang, Junjun ; Hudek, Alexander K. ; Li, Martin ; Haddad, May ; Duggan, Gavin E. ; Fernandez, Bridget A. ; Kanematsu, Emiko ; Gentles, Simone ; Christopoulos, Constantine C. ; Choufani, Sanaa ; Kwasnicka, Dorota ; Zheng, Xiangqun H. ; Lai, Zhongwu ; Nusskern, Deborah ; Zhang, Qing ; Gu, Zhiping ; Lu, Fu ; Zeesman, Susan ; Nowaczyk, Malgorzata J. ; Teshima, Ikuko ; Chitayat, David ; Shuman, Cheryl ; Weksberg, Rosanna ; Zackai, Elaine H. ; Grebe, Theresa A. ; Cox, Sarah R. ; Kirkpatrick, Susan J. ; Rahman, Nazneen ; Friedman, Jan M. ; Heng, Henry H.Q. ; Pelicci, Pier Giuseppe ; Lo-Coco, Francesco ; Belloni, Elena ; Shaffer, Lisa G. ; Pober, Barbara ; Morton, Cynthia C. ; Gusella, James F. ; Bruns, Gail A.P. ; Korf, Bruce R. ; Quade, Bradley J. ; Ligon, Azra H. ; Ferguson, Heather ; Higgins, Anne W. ; Leach, Natalia T. ; Herrick, Steven R. ; Lemyre, Emmanuelle ; Farra, Chantal G. ; Kim, Hyung Goo ; Summers, Anne M. ; Gripp, Karen W. ; Roberts, Wendy ; Szatmari, Peter ; Winsor, Elizabeth J.T. ; Grzeschik, Karl Heinz ; Teebi, Ahmed ; Minassian, Berge A. ; Kere, Juha ; Armengol, Luis ; Pujana, Miguel Angel ; Estivill, Xavier ; Wilson, Michael D. ; Koop, Ben F. ; Tosi, Sabrina ; Moore, Gudrun E. ; Boright, Andrew P. ; Zlotorynski, Eitan ; Kerem, Batsheva ; Kroisel, Peter M. ; Petek, Erwin ; Oscier, David G. ; Mould, Sarah J. ; Döhner, Hartmut ; Döhner, Konstanze ; Rommens, Johanna M. ; Vincent, John B. ; Venter, J. Craig ; Li, Peter W. ; Mural, Richard J. ; Adams, Mark D. ; Tsui, Lap Chee. / Human chromosome 7 : DNA sequence and biology. In: Science. 2003 ; Vol. 300, No. 5620. pp. 767-772.
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T1 - Human chromosome 7

T2 - DNA sequence and biology

AU - Scherer, Stephen W.

AU - Cheung, Joseph

AU - MacDonald, Jeffrey R.

AU - Osborne, Lucy R.

AU - Nakabayashi, Kazuhiko

AU - Herbrick, Jo Anne

AU - Carson, Andrew R.

AU - Parker-Katiraee, Layla

AU - Skaug, Jennifer

AU - Khaja, Razi

AU - Zhang, Junjun

AU - Hudek, Alexander K.

AU - Li, Martin

AU - Haddad, May

AU - Duggan, Gavin E.

AU - Fernandez, Bridget A.

AU - Kanematsu, Emiko

AU - Gentles, Simone

AU - Christopoulos, Constantine C.

AU - Choufani, Sanaa

AU - Kwasnicka, Dorota

AU - Zheng, Xiangqun H.

AU - Lai, Zhongwu

AU - Nusskern, Deborah

AU - Zhang, Qing

AU - Gu, Zhiping

AU - Lu, Fu

AU - Zeesman, Susan

AU - Nowaczyk, Malgorzata J.

AU - Teshima, Ikuko

AU - Chitayat, David

AU - Shuman, Cheryl

AU - Weksberg, Rosanna

AU - Zackai, Elaine H.

AU - Grebe, Theresa A.

AU - Cox, Sarah R.

AU - Kirkpatrick, Susan J.

AU - Rahman, Nazneen

AU - Friedman, Jan M.

AU - Heng, Henry H.Q.

AU - Pelicci, Pier Giuseppe

AU - Lo-Coco, Francesco

AU - Belloni, Elena

AU - Shaffer, Lisa G.

AU - Pober, Barbara

AU - Morton, Cynthia C.

AU - Gusella, James F.

AU - Bruns, Gail A.P.

AU - Korf, Bruce R.

AU - Quade, Bradley J.

AU - Ligon, Azra H.

AU - Ferguson, Heather

AU - Higgins, Anne W.

AU - Leach, Natalia T.

AU - Herrick, Steven R.

AU - Lemyre, Emmanuelle

AU - Farra, Chantal G.

AU - Kim, Hyung Goo

AU - Summers, Anne M.

AU - Gripp, Karen W.

AU - Roberts, Wendy

AU - Szatmari, Peter

AU - Winsor, Elizabeth J.T.

AU - Grzeschik, Karl Heinz

AU - Teebi, Ahmed

AU - Minassian, Berge A.

AU - Kere, Juha

AU - Armengol, Luis

AU - Pujana, Miguel Angel

AU - Estivill, Xavier

AU - Wilson, Michael D.

AU - Koop, Ben F.

AU - Tosi, Sabrina

AU - Moore, Gudrun E.

AU - Boright, Andrew P.

AU - Zlotorynski, Eitan

AU - Kerem, Batsheva

AU - Kroisel, Peter M.

AU - Petek, Erwin

AU - Oscier, David G.

AU - Mould, Sarah J.

AU - Döhner, Hartmut

AU - Döhner, Konstanze

AU - Rommens, Johanna M.

AU - Vincent, John B.

AU - Venter, J. Craig

AU - Li, Peter W.

AU - Mural, Richard J.

AU - Adams, Mark D.

AU - Tsui, Lap Chee

PY - 2003/5/2

Y1 - 2003/5/2

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