Human cytochromes P450

Julia A. Hasler, Ronald Estabrook, Michael Murray, Irina Pikuleva, Michael Waterman, Jorge Capdevila, Vijakumar Holla, Christian Helvig, J R Falck, Geoffrey Farrell, Laurence S. Kaminsky, Simon D. Spivack, Eric Boitier, Philippe Beaune

Research output: Contribution to journalReview article

132 Scopus citations

Abstract

The cytochrome P450 proteins (CYPs) are a family of haem proteins resulting from expression of a gene super-family that currently contains around 1000 members in species ranging from bacteria through to plants and animals. In humans, about 40 different CYPs are present and these play critical roles by catalyzing reactions in: (a) the metabolism of drugs, environmental pollutants and other xenobiotics; (b) the biosynthesis of steroid hormones; (c) the oxidation of unsaturated fatty acids to intracellular messengers; and (d) the stereo- and regio-specific metabolism of fat-soluble vitamins. This review deals with aspects of cytochrome P450s of relevance to human physiology, biochemistry, pharmacology and medicine. Topics reviewed include: pharmacogenetics of CYPs, induction and inhibition of these haem proteins, their role in metabolism of endogenous compounds such as steroids and eicosanoids, the effect of disease on CYP function, CYPs and cancer, and CYPs as targets of antibodies in immune-mediated diseases. Copyright (C) 1999 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)1-137
Number of pages137
JournalMolecular aspects of medicine
Volume20
Issue number1-2
DOIs
StatePublished - Feb 1 1999

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Keywords

  • Autoantibodies
  • Cancer
  • Chemical carcinogenesis
  • Cytochrome P450
  • Disease
  • Drug metabolism
  • Eicosaniod metabolism
  • Fatty acid epoxidation
  • Genetic polymorphisms
  • Steroid hormone synthesis
  • Xenobiotics

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry

Cite this

Hasler, J. A., Estabrook, R., Murray, M., Pikuleva, I., Waterman, M., Capdevila, J., Holla, V., Helvig, C., Falck, J. R., Farrell, G., Kaminsky, L. S., Spivack, S. D., Boitier, E., & Beaune, P. (1999). Human cytochromes P450. Molecular aspects of medicine, 20(1-2), 1-137. https://doi.org/10.1016/S0098-2997(99)00005-9