Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene

Luis F. Parada, Clifford J. Tabin, Chiaho Shih, Robert A. Weinberg

Research output: Contribution to journalArticle

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Abstract

Examination of homologies between retroviral oncogenes and transforming sequences defined by transfection reveals that the human bladder carcinoma (EJ) oncogene is homologous to the Harvey sarcoma virus oncogene (ras). Structural analysis limits the region of homology to a 3.0-kilobase SacI fragment of the EJ oncogene. Both EJ and ras DNA probes detect similar transcripts in transfectants derived from bladder carcinoma cell lines.

Original languageEnglish (US)
Pages (from-to)474-478
Number of pages5
JournalNature
Volume297
Issue number5866
DOIs
StatePublished - 1982

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Harvey murine sarcoma virus
ras Genes
Oncogenes
Urinary Bladder
Carcinoma
DNA Probes
Transfection
Cell Line

ASJC Scopus subject areas

  • General

Cite this

Parada, L. F., Tabin, C. J., Shih, C., & Weinberg, R. A. (1982). Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene. Nature, 297(5866), 474-478. https://doi.org/10.1038/297474a0

Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene. / Parada, Luis F.; Tabin, Clifford J.; Shih, Chiaho; Weinberg, Robert A.

In: Nature, Vol. 297, No. 5866, 1982, p. 474-478.

Research output: Contribution to journalArticle

Parada, LF, Tabin, CJ, Shih, C & Weinberg, RA 1982, 'Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene', Nature, vol. 297, no. 5866, pp. 474-478. https://doi.org/10.1038/297474a0
Parada, Luis F. ; Tabin, Clifford J. ; Shih, Chiaho ; Weinberg, Robert A. / Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene. In: Nature. 1982 ; Vol. 297, No. 5866. pp. 474-478.
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