Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene

Luis F. Parada, Clifford J. Tabin, Chiaho Shih, Robert A. Weinberg

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545 Scopus citations

Abstract

Examination of homologies between retroviral oncogenes and transforming sequences defined by transfection reveals that the human bladder carcinoma (EJ) oncogene is homologous to the Harvey sarcoma virus oncogene (ras). Structural analysis limits the region of homology to a 3.0-kilobase SacI fragment of the EJ oncogene. Both EJ and ras DNA probes detect similar transcripts in transfectants derived from bladder carcinoma cell lines.

Original languageEnglish (US)
Pages (from-to)474-478
Number of pages5
JournalNature
Volume297
Issue number5866
DOIs
StatePublished - Dec 1 1982

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    Parada, L. F., Tabin, C. J., Shih, C., & Weinberg, R. A. (1982). Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene. Nature, 297(5866), 474-478. https://doi.org/10.1038/297474a0