Abstract

Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem that affects one-third of adults and an increasing number of children in developed countries. The disease begins with the aberrant accumulation of triglyceride in the liver, which in some individuals elicits an inflammatory response that can progress to cirrhosis and liver cancer. Although NAFLD is strongly associated with obesity and insulin resistance, its pathogenesis remains poorly understood, and therapeutic options are limited. Here, we discuss recent mechanistic insights into NAFLD, focusing primarily on those that have emerged from human genetic and metabolic studies.

Original languageEnglish (US)
Pages (from-to)1519-1523
Number of pages5
JournalScience
Volume332
Issue number6037
DOIs
StatePublished - Jun 24 2011

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Fatty Liver
Liver Diseases
Medical Genetics
Liver Neoplasms
Developed Countries
Insulin Resistance
Triglycerides
Fibrosis
Obesity
Liver
Health
Non-alcoholic Fatty Liver Disease
Therapeutics

ASJC Scopus subject areas

  • General

Cite this

Human fatty liver disease : Old questions and new insights. / Cohen, Jonathan C.; Horton, Jay D.; Hobbs, Helen H.

In: Science, Vol. 332, No. 6037, 24.06.2011, p. 1519-1523.

Research output: Contribution to journalArticle

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