Human herpesvirus 1 UL24 gene encodes a potential PD-(D/E)XK endonuclease

Łukasz Knizewski, Lisa Kinch, Nick V. Grishin, Leszek Rychlewski, Krzysztof Ginalski

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Using Meta-BASIC, a highly sensitive method for detection of distant similarity between proteins, we have identified another potential PD-(D/E)XK endonuclease in human herpesvirus 1 (HHV-1) encoded by the UL24 gene. The universal presence of UL24 in completed herpesviral genomes of three major subfamilies, Alphaherpesvirinae, Betaherpesvirinae, and Gammaherpesvirinae, suggests a fundamental role for this predicted PD-(D/E)XK endonuclease activity in the viral life cycle.

Original languageEnglish (US)
Pages (from-to)2575-2577
Number of pages3
JournalJournal of Virology
Volume80
Issue number5
DOIs
StatePublished - Mar 2006

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Betaherpesvirinae
Gammaherpesvirinae
Alphaherpesvirinae
Human herpesvirus 1
Endonucleases
Human Herpesvirus 1
life cycle (organisms)
genome
Life Cycle Stages
Genes
genes
proteins
Genome
methodology
Proteins

ASJC Scopus subject areas

  • Immunology

Cite this

Human herpesvirus 1 UL24 gene encodes a potential PD-(D/E)XK endonuclease. / Knizewski, Łukasz; Kinch, Lisa; Grishin, Nick V.; Rychlewski, Leszek; Ginalski, Krzysztof.

In: Journal of Virology, Vol. 80, No. 5, 03.2006, p. 2575-2577.

Research output: Contribution to journalArticle

Knizewski, Łukasz ; Kinch, Lisa ; Grishin, Nick V. ; Rychlewski, Leszek ; Ginalski, Krzysztof. / Human herpesvirus 1 UL24 gene encodes a potential PD-(D/E)XK endonuclease. In: Journal of Virology. 2006 ; Vol. 80, No. 5. pp. 2575-2577.
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