Human herpesvirus 6-induced inflammatory cardiomyopathy in immunocompetent children

Surabhi Reddy, Eva Eliassen, Gerhard R. Krueger, Bibhuti B. Das

Research output: Contribution to journalReview article

Abstract

Over the last decade, human herpesvirus 6 (HHV-6) has been implicated in the etiology of pediatric myocarditis and subsequent dilated cardiomyopathy (DCM). This review provides an overview of recent literature investigating the pathophysiological relevance of HHV-6 in inflammatory cardiomyopathy. We examined 11 cases of previously published pediatric myocarditis and/or DCM associated with HHV-6 and also our experience of detection of virus particles in vascular endothelium of HHV-6 positive endomyocardial biopsy tissue by electron microscopy. The exact role of the presence of HHV-6 and its load remains controversial as the virus is also found in the heart of healthy controls. Therefore, the question remains open whether and how cardiac HHV-6 may be of pathogenetic importance. Quantitative polymerase chain reaction or mRNA testing allows differentiation between low-level latent virus found in asymptomatic myocardium and active HHV-6 infection. Although only a small number of pediatric cases have been reported in literature, HHV-6 should be considered as a causative agent of inflammatory cardiomyopathy, especially in children under three who might be experiencing a primary infection. Future studies are needed to establish a threshold for determining active infection in biopsy samples and the role of coinfections other cardiotropic viruses.

Original languageEnglish (US)
Pages (from-to)259-268
Number of pages10
JournalAnnals of Pediatric Cardiology
Volume10
Issue number3
DOIs
StatePublished - Sep 1 2017

Fingerprint

Human Herpesvirus 6
Cardiomyopathies
Myocarditis
Dilated Cardiomyopathy
Pediatrics
Viruses
Biopsy
Herpesviridae Infections
Vascular Endothelium
Infection
Coinfection
Virion
Myocardium
Electron Microscopy
Polymerase Chain Reaction
Messenger RNA

Keywords

  • Human herpesvirus 6 cardiomyopathy
  • myocarditis in children
  • pediatric-dilated cardiomyopathy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Cardiology and Cardiovascular Medicine

Cite this

Human herpesvirus 6-induced inflammatory cardiomyopathy in immunocompetent children. / Reddy, Surabhi; Eliassen, Eva; Krueger, Gerhard R.; Das, Bibhuti B.

In: Annals of Pediatric Cardiology, Vol. 10, No. 3, 01.09.2017, p. 259-268.

Research output: Contribution to journalReview article

Reddy, Surabhi ; Eliassen, Eva ; Krueger, Gerhard R. ; Das, Bibhuti B. / Human herpesvirus 6-induced inflammatory cardiomyopathy in immunocompetent children. In: Annals of Pediatric Cardiology. 2017 ; Vol. 10, No. 3. pp. 259-268.
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