Abstract
The emergence of HIV/AIDS more than three decades ago led to an increased incidence of diseases caused by HHV8 co-infection, particularly Kaposi sarcoma, primary effusion lymphoma, and multicentric Castleman disease. Over time, the development of highly effective AIDS therapies has resulted in a decreased incidence of HHV8-associated entities, which are now more commonly found in patients with undiagnosed and/or untreated AIDS. Due to their rarity, some of these diseases may be difficult to recognize without appropriate clinical information. This article provides an overview of HHV8-related disorders, with a focus on their morphologic and phenotypic features, and includes a brief overview of laboratory methods used to detect HHV8. Disease mechanisms by which the HHV8 virion promotes tumorigenesis are also reviewed.
Original language | English (US) |
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Pages (from-to) | 371-376 |
Number of pages | 6 |
Journal | Seminars in Diagnostic Pathology |
Volume | 34 |
Issue number | 4 |
DOIs | |
State | Published - Jul 2017 |
Externally published | Yes |
Keywords
- AIDS
- Castleman
- HHV8
- Kaposi
- Primary effusion lymphoma
ASJC Scopus subject areas
- Pathology and Forensic Medicine