H-2 LD antigens1 of the mouse major histocompatibility complex and the lymphocyte-activating determinants of the Mls (ref. 2) locus induce vigorous lymphocyte proliferation and enhance generation of cytotoxic effector cells in allogeneic combinations (ref. 3 and D. J. Schendel, and F. H. Bach, unpublished). These antigens do not serve well as targets for cell-mediated lympholysis (CML) - a function which in the mouse is performed by the classical H-2 determinants, the SD antigens4,5. A similar differential function of LD and SD antigens is found in human allograft reactions in vitro 6.
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