Human metapneumovirus: A newly emerging respiratory pathogen

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Purpose of review: The present review focuses on the recent discovery, and clinical and epidemiological features of a virus associated with respiratory tract infections. Recent findings: In June 2001, researchers in The Netherlands reported the discovery of a virus associated with respiratory tract disease in infants and children. Genetic studies of this newly discovered viral pathogen revealed that it was a paramyxovirus. This virus is the first human pathogen in the Genus Metapneumovirus and was called human metapneumovirus (hMPV). hMPV may be a common respiratory virus. Seroepidemiologic studies in The Netherlands suggested that, by age 5 years, nearly all individuals have been exposed to hMPV. The results of several studies suggest that hMPV may account for about 10% of respiratory tract infections in which a common respiratory virus, such as respiratory syncytial virus, or influenza or parainfluenza viruses, could not be detected, hMPV has been detected in patients with either upper or lower respiratory tract disease, or both. Symptoms associated with hMPV include cough, dyspnea, wheeze, and hypoxia. This newly recognized pathogen has been detected in children and adults. Epidemiological findings suggest that it may circulate worldwide and may have a seasonal distribution. Summary: hMPV is a newly emerging respiratory pathogen and may be the cause of a significant proportion of both upper and lower respiratory tract infection in infants, children, and adults.

Original languageEnglish (US)
Pages (from-to)255-258
Number of pages4
JournalCurrent Opinion in Infectious Diseases
Volume16
Issue number3
StatePublished - Jun 2003

Fingerprint

Metapneumovirus
Viruses
Respiratory Tract Infections
Respiratory Tract Diseases
Netherlands
Paramyxoviridae Infections
Respiratory Syncytial Viruses
Seroepidemiologic Studies
Cough
Dyspnea
Human Influenza
Research Personnel

Keywords

  • Human metapneumovirus
  • Respiratory tract infection

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology

Cite this

Human metapneumovirus : A newly emerging respiratory pathogen. / Kahn, Jeffrey.

In: Current Opinion in Infectious Diseases, Vol. 16, No. 3, 06.2003, p. 255-258.

Research output: Contribution to journalArticle

@article{d3c630411df8445e9469ba09e4d263ec,
title = "Human metapneumovirus: A newly emerging respiratory pathogen",
abstract = "Purpose of review: The present review focuses on the recent discovery, and clinical and epidemiological features of a virus associated with respiratory tract infections. Recent findings: In June 2001, researchers in The Netherlands reported the discovery of a virus associated with respiratory tract disease in infants and children. Genetic studies of this newly discovered viral pathogen revealed that it was a paramyxovirus. This virus is the first human pathogen in the Genus Metapneumovirus and was called human metapneumovirus (hMPV). hMPV may be a common respiratory virus. Seroepidemiologic studies in The Netherlands suggested that, by age 5 years, nearly all individuals have been exposed to hMPV. The results of several studies suggest that hMPV may account for about 10{\%} of respiratory tract infections in which a common respiratory virus, such as respiratory syncytial virus, or influenza or parainfluenza viruses, could not be detected, hMPV has been detected in patients with either upper or lower respiratory tract disease, or both. Symptoms associated with hMPV include cough, dyspnea, wheeze, and hypoxia. This newly recognized pathogen has been detected in children and adults. Epidemiological findings suggest that it may circulate worldwide and may have a seasonal distribution. Summary: hMPV is a newly emerging respiratory pathogen and may be the cause of a significant proportion of both upper and lower respiratory tract infection in infants, children, and adults.",
keywords = "Human metapneumovirus, Respiratory tract infection",
author = "Jeffrey Kahn",
year = "2003",
month = "6",
language = "English (US)",
volume = "16",
pages = "255--258",
journal = "Current Opinion in Infectious Diseases",
issn = "0951-7375",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Human metapneumovirus

T2 - A newly emerging respiratory pathogen

AU - Kahn, Jeffrey

PY - 2003/6

Y1 - 2003/6

N2 - Purpose of review: The present review focuses on the recent discovery, and clinical and epidemiological features of a virus associated with respiratory tract infections. Recent findings: In June 2001, researchers in The Netherlands reported the discovery of a virus associated with respiratory tract disease in infants and children. Genetic studies of this newly discovered viral pathogen revealed that it was a paramyxovirus. This virus is the first human pathogen in the Genus Metapneumovirus and was called human metapneumovirus (hMPV). hMPV may be a common respiratory virus. Seroepidemiologic studies in The Netherlands suggested that, by age 5 years, nearly all individuals have been exposed to hMPV. The results of several studies suggest that hMPV may account for about 10% of respiratory tract infections in which a common respiratory virus, such as respiratory syncytial virus, or influenza or parainfluenza viruses, could not be detected, hMPV has been detected in patients with either upper or lower respiratory tract disease, or both. Symptoms associated with hMPV include cough, dyspnea, wheeze, and hypoxia. This newly recognized pathogen has been detected in children and adults. Epidemiological findings suggest that it may circulate worldwide and may have a seasonal distribution. Summary: hMPV is a newly emerging respiratory pathogen and may be the cause of a significant proportion of both upper and lower respiratory tract infection in infants, children, and adults.

AB - Purpose of review: The present review focuses on the recent discovery, and clinical and epidemiological features of a virus associated with respiratory tract infections. Recent findings: In June 2001, researchers in The Netherlands reported the discovery of a virus associated with respiratory tract disease in infants and children. Genetic studies of this newly discovered viral pathogen revealed that it was a paramyxovirus. This virus is the first human pathogen in the Genus Metapneumovirus and was called human metapneumovirus (hMPV). hMPV may be a common respiratory virus. Seroepidemiologic studies in The Netherlands suggested that, by age 5 years, nearly all individuals have been exposed to hMPV. The results of several studies suggest that hMPV may account for about 10% of respiratory tract infections in which a common respiratory virus, such as respiratory syncytial virus, or influenza or parainfluenza viruses, could not be detected, hMPV has been detected in patients with either upper or lower respiratory tract disease, or both. Symptoms associated with hMPV include cough, dyspnea, wheeze, and hypoxia. This newly recognized pathogen has been detected in children and adults. Epidemiological findings suggest that it may circulate worldwide and may have a seasonal distribution. Summary: hMPV is a newly emerging respiratory pathogen and may be the cause of a significant proportion of both upper and lower respiratory tract infection in infants, children, and adults.

KW - Human metapneumovirus

KW - Respiratory tract infection

UR - http://www.scopus.com/inward/record.url?scp=0037607129&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037607129&partnerID=8YFLogxK

M3 - Article

C2 - 12821817

AN - SCOPUS:0037607129

VL - 16

SP - 255

EP - 258

JO - Current Opinion in Infectious Diseases

JF - Current Opinion in Infectious Diseases

SN - 0951-7375

IS - 3

ER -