Human metapneumovirus and exacerbations of chronic obstructive pulmonary disease

Richard A. Martinello, Frank Esper, Carla Weibel, David Ferguson, Marie L. Landry, Jeffrey Kahn

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

Objective: Respiratory viruses are a common trigger for exacerbations of chronic obstructive pulmonary disease (COPD). Human metapneumovirus (hMPV) is a paramyxovirus associated with respiratory tract infections and wheezing. Our aim was to determine whether hMPV was associated with exacerbations of COPD. Methods: The study was designed as an observational cohort study carried out in a 944-bed urban teaching hospital located in New Haven, Connecticut. Between December 2002 and May 2003, patients hospitalized due to an exacerbation of COPD were identified. Nasopharyngeal specimens obtained from these patients were tested for human metapneumovirus by RT-PCR and for respiratory syncytial virus, influenza A and B, parainfluenza-1, -2, and -3 and adenovirus by a cytospin-enhanced direct immunofluorescence assay and/or viral culture. Results: Fifty individuals met enrollment criteria and hMPV was identified in 6 (12%), respiratory syncytial virus in 4 (8%), influenza A in 2 (4%) and parainfluenza type 3 in 1 (2%) patients. Both A and B hMPV genotypes were identified in patients hospitalized due to exacerbations of COPD. Conclusion: hMPV was frequently identified in patients hospitalized due to an exacerbation of COPD. Further studies are necessary to determine the epidemiology and the impact of hMPV in COPD patients.

Original languageEnglish (US)
Pages (from-to)248-254
Number of pages7
JournalJournal of Infection
Volume53
Issue number4
DOIs
StatePublished - Oct 1 2006

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Keywords

  • Lung disease
  • Metapneumovirus
  • Obstructive lung disease
  • Paramyxoviridae infection

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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