TY - JOUR
T1 - Human metapneumovirus and exacerbations of chronic obstructive pulmonary disease
AU - Martinello, Richard A.
AU - Esper, Frank
AU - Weibel, Carla
AU - Ferguson, David
AU - Landry, Marie L.
AU - Kahn, Jeffrey
N1 - Funding Information:
We are indebted to Eugene D. Shapiro for his critical review of the manuscript and insightful comments. We are also indebted to the staff of the Clinical Virology Laboratory, Linda Selander for her assistance in Medical Records and Bobbie Welch for assisting with patient surveillance. This work was supported by The Patrick and Catherine Weldon Donaghue Medical Research Foundation (J.S.K.) and the William Wirt Winchester Foundation (R.A.M.). This work was also supported in part by the Yale Children's Clinical Research Center grant M01-RR06022 (J.S.K.), General Clinical Research Centers Program, National Center for Research Resources, National Institutes of Health and by National Institutes of Health grants T32 AI07210-20 (F.E.) and F32 AI055151 (F.E.). The authors do not claim conflict of interest related to the material presented herein.
PY - 2006/10
Y1 - 2006/10
N2 - Objective: Respiratory viruses are a common trigger for exacerbations of chronic obstructive pulmonary disease (COPD). Human metapneumovirus (hMPV) is a paramyxovirus associated with respiratory tract infections and wheezing. Our aim was to determine whether hMPV was associated with exacerbations of COPD. Methods: The study was designed as an observational cohort study carried out in a 944-bed urban teaching hospital located in New Haven, Connecticut. Between December 2002 and May 2003, patients hospitalized due to an exacerbation of COPD were identified. Nasopharyngeal specimens obtained from these patients were tested for human metapneumovirus by RT-PCR and for respiratory syncytial virus, influenza A and B, parainfluenza-1, -2, and -3 and adenovirus by a cytospin-enhanced direct immunofluorescence assay and/or viral culture. Results: Fifty individuals met enrollment criteria and hMPV was identified in 6 (12%), respiratory syncytial virus in 4 (8%), influenza A in 2 (4%) and parainfluenza type 3 in 1 (2%) patients. Both A and B hMPV genotypes were identified in patients hospitalized due to exacerbations of COPD. Conclusion: hMPV was frequently identified in patients hospitalized due to an exacerbation of COPD. Further studies are necessary to determine the epidemiology and the impact of hMPV in COPD patients.
AB - Objective: Respiratory viruses are a common trigger for exacerbations of chronic obstructive pulmonary disease (COPD). Human metapneumovirus (hMPV) is a paramyxovirus associated with respiratory tract infections and wheezing. Our aim was to determine whether hMPV was associated with exacerbations of COPD. Methods: The study was designed as an observational cohort study carried out in a 944-bed urban teaching hospital located in New Haven, Connecticut. Between December 2002 and May 2003, patients hospitalized due to an exacerbation of COPD were identified. Nasopharyngeal specimens obtained from these patients were tested for human metapneumovirus by RT-PCR and for respiratory syncytial virus, influenza A and B, parainfluenza-1, -2, and -3 and adenovirus by a cytospin-enhanced direct immunofluorescence assay and/or viral culture. Results: Fifty individuals met enrollment criteria and hMPV was identified in 6 (12%), respiratory syncytial virus in 4 (8%), influenza A in 2 (4%) and parainfluenza type 3 in 1 (2%) patients. Both A and B hMPV genotypes were identified in patients hospitalized due to exacerbations of COPD. Conclusion: hMPV was frequently identified in patients hospitalized due to an exacerbation of COPD. Further studies are necessary to determine the epidemiology and the impact of hMPV in COPD patients.
KW - Lung disease
KW - Metapneumovirus
KW - Obstructive lung disease
KW - Paramyxoviridae infection
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U2 - 10.1016/j.jinf.2005.11.010
DO - 10.1016/j.jinf.2005.11.010
M3 - Article
C2 - 16412516
AN - SCOPUS:33746327008
SN - 0163-4453
VL - 53
SP - 248
EP - 254
JO - Journal of Infection
JF - Journal of Infection
IS - 4
ER -