Human muscle sympathetic nerve activity and plasma noradrenaline kinetics in space

Andrew C. Ertl, André Diedrich, Italo Biaggioni, Benjamin D. Levine, Rose Marie Robertson, James F. Cox, Julie H. Zuckerman, James A. Pawelczykd, Chester A. Ray, Jay C. Buckey, Lynda D. Lane, Richard Shiavi, F. Andrew Gaffney, Fernando Costa, Carol Holt, C. Andrew Blomqvist, Dwain L. Eckberg, Friedhelm J. Baisch, David Robertson

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Astronauts returning from space have reduced red blood cell masses, hypovolaemia and orthostatic intolerance, marked by greater cardio-acceleration during standing than before spaceflight, and in some, orthostatic hypotension and presyncope. Adaptation of the sympathetic nervous system occurring during spaceflight may be responsible for these postflight alterations. We tested the hypotheses that exposure to microgravity reduces sympathetic neural outflow and impairs sympathetic neural responses to orthostatic stress. We measured heart rate, photoplethysmographic finger arterial pressure, peroneal nerve muscle sympathetic activity and plasma noradrenaline spillover and clearance, in male astronauts before, during (flight day 12 or 13) and after the 16 day Neurolab space shuttle mission. Measurements were made during supine rest and orthostatic stress, as simulated on Earth and in space by 7 min periods of 15 and 30 mmHg lower body suction. Mean (± S.E.M.) heart rates before lower body suction were similar pre-flight and in flight. Heart rate responses to -30 mmHg were greater in flight (from 56 ± 4 to 72 ± 4 beats min-1) than pre-flight (from 56 ± 4 at rest to 62 ± 4 beats min-1, P < 0.05). Noradrenaline spillover and clearance were increased from pre-flight levels during baseline periods and during lower body suction, both in flight (n = 3) and on post-flight days 1 or 2 (n = 5, P < 0.05). In-flight baseline sympathetic nerve activity was increased above pre-flight levels (by 10-33%) in the same three subjects in whom noradrenaline spillover and clearance were increased. The sympathetic response to 30 mmHg lower body suction was at pre-flight levels or higher in each subject (35 pre-flight vs. 40 bursts min-1 in flight). No astronaut experienced presyncope during lower body suction in space (or during upright tilt following the Neurolab mission). We conclude that in space, baseline sympathetic neural outflow is increased moderately and sympathetic responses to lower body suction are exaggerated. Therefore, notwithstanding hypovolaemia,astronauts respond normally to simulated orthostatic stress and are able to maintain their arterial pressures at normal levels.

Original languageEnglish (US)
Pages (from-to)321-329
Number of pages9
JournalJournal of Physiology
Volume538
Issue number1
DOIs
StatePublished - Jan 1 2002

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Suction
Astronauts
Norepinephrine
Muscles
Space Flight
Hypovolemia
Heart Rate
Syncope
Arterial Pressure
Orthostatic Intolerance
Erythrocyte Volume
Weightlessness
Peroneal Nerve
Orthostatic Hypotension
Sympathetic Nervous System
Fingers
Erythrocytes

ASJC Scopus subject areas

  • Physiology

Cite this

Ertl, A. C., Diedrich, A., Biaggioni, I., Levine, B. D., Robertson, R. M., Cox, J. F., ... Robertson, D. (2002). Human muscle sympathetic nerve activity and plasma noradrenaline kinetics in space. Journal of Physiology, 538(1), 321-329. https://doi.org/10.1113/jphysiol.2001.012576

Human muscle sympathetic nerve activity and plasma noradrenaline kinetics in space. / Ertl, Andrew C.; Diedrich, André; Biaggioni, Italo; Levine, Benjamin D.; Robertson, Rose Marie; Cox, James F.; Zuckerman, Julie H.; Pawelczykd, James A.; Ray, Chester A.; Buckey, Jay C.; Lane, Lynda D.; Shiavi, Richard; Gaffney, F. Andrew; Costa, Fernando; Holt, Carol; Blomqvist, C. Andrew; Eckberg, Dwain L.; Baisch, Friedhelm J.; Robertson, David.

In: Journal of Physiology, Vol. 538, No. 1, 01.01.2002, p. 321-329.

Research output: Contribution to journalArticle

Ertl, AC, Diedrich, A, Biaggioni, I, Levine, BD, Robertson, RM, Cox, JF, Zuckerman, JH, Pawelczykd, JA, Ray, CA, Buckey, JC, Lane, LD, Shiavi, R, Gaffney, FA, Costa, F, Holt, C, Blomqvist, CA, Eckberg, DL, Baisch, FJ & Robertson, D 2002, 'Human muscle sympathetic nerve activity and plasma noradrenaline kinetics in space', Journal of Physiology, vol. 538, no. 1, pp. 321-329. https://doi.org/10.1113/jphysiol.2001.012576
Ertl, Andrew C. ; Diedrich, André ; Biaggioni, Italo ; Levine, Benjamin D. ; Robertson, Rose Marie ; Cox, James F. ; Zuckerman, Julie H. ; Pawelczykd, James A. ; Ray, Chester A. ; Buckey, Jay C. ; Lane, Lynda D. ; Shiavi, Richard ; Gaffney, F. Andrew ; Costa, Fernando ; Holt, Carol ; Blomqvist, C. Andrew ; Eckberg, Dwain L. ; Baisch, Friedhelm J. ; Robertson, David. / Human muscle sympathetic nerve activity and plasma noradrenaline kinetics in space. In: Journal of Physiology. 2002 ; Vol. 538, No. 1. pp. 321-329.
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