Human ovarian tissue cortex surrounding benign and malignant lesions

Mary Ellen Pavone, Jennifer Hirshfeld-Cytron, Candace Tingen, Cristina Thomas, Jessina Thomas, M. Patrick Lowe, Julian C. Schink, Teresa K. Woodruff

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Objective: To quantify the number of follicles in patients with ovarian pathologies, benign and malignant, in pregnant and nonpregnant states and to determine how the presence of ovarian masses and BRCA status affects follicular counts. Materials and Methods: Slides from 134 reproductive-aged women undergoing oophorectomy were examined using light microscopy by 3 independent counters blinded to the diagnosis. In all, 20 patients had cancer, 69 had benign conditions, and 35 patients were BRCA or had a strong family history of breast and/or ovarian cancer. In all, 10 women were either pregnant or immediately postpartum. Results: Patients undergoing risk-reducing surgery had significantly decreased follicle count compared to physiologic control. Patients with cancer had significantly decreased counts compared to all other groups. There were no differences within the benign cohort. Conclusions: When compared to benign masses, the cortex surrounding an ovarian malignancy has decreased follicle density. The stretch impact may minimize any impact on total follicle numbers. Furthermore, there may be a proliferation of ovarian stroma, with the same number of follicles spread over a larger surface area. This information is important when counseling women with ovarian masses regarding the use of ovarian tissue cryopreservation.

Original languageEnglish (US)
Pages (from-to)582-589
Number of pages8
JournalReproductive Sciences
Volume21
Issue number5
DOIs
StatePublished - May 2014
Externally publishedYes

Keywords

  • endometriosis
  • fertility preservation
  • follicle density
  • ovarian cancer
  • ovarian tissue cryopreservation
  • ovarian tissue transplantation

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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