TY - JOUR
T1 - Human papillomavirus (HPV) vaccine and autonomic disorders
T2 - a position statement from the American Autonomic Society
AU - on behalf of the American Autonomic Society
AU - Barboi, Alexandru
AU - Gibbons, Christopher H.
AU - Axelrod, Felicia
AU - Benarroch, Eduardo E.
AU - Biaggioni, Italo
AU - Chapleau, Mark W.
AU - Chelimsky, Gisela
AU - Chelimsky, Thomas
AU - Cheshire, William P.
AU - Claydon, Victoria E.
AU - Freeman, Roy
AU - Goldstein, David S.
AU - Joyner, Michael J.
AU - Kaufmann, Horacio
AU - Low, Phillip A.
AU - Norcliffe-Kaufmann, Lucy
AU - Robertson, David
AU - Shibao, Cyndya A.
AU - Singer, Wolfgang
AU - Snapper, Howard
AU - Vernino, Steven
AU - Raj, Satish R.
N1 - Publisher Copyright:
© 2019, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2020/2/1
Y1 - 2020/2/1
N2 - Introduction: Human papillomavirus (HPV) vaccination has been anecdotally connected to the development of dysautonomia, chronic fatigue, complex regional pain syndrome and postural tachycardia syndrome. Objectives: To critically evaluate a potential connection between HPV vaccination and the above-noted conditions. Methods: We reviewed the literature containing the biology of the virus, pathophysiology of infection, epidemiology of associated cancers, indications of HPV vaccination, safety surveillance data and published reports linking HPV vaccination to autonomic disorders. Results: At this time, the American Autonomic Society finds that there are no data to support a causal relationship between HPV vaccination and CRPS, chronic fatigue, and postural tachycardia syndrome to other forms of dysautonomia. Conclusion: Certain conditions are prevalent in the same populations that are vaccinated with the HPV vaccine (peri-pubertal males and females). This association, however, is an insufficient proof of causality.
AB - Introduction: Human papillomavirus (HPV) vaccination has been anecdotally connected to the development of dysautonomia, chronic fatigue, complex regional pain syndrome and postural tachycardia syndrome. Objectives: To critically evaluate a potential connection between HPV vaccination and the above-noted conditions. Methods: We reviewed the literature containing the biology of the virus, pathophysiology of infection, epidemiology of associated cancers, indications of HPV vaccination, safety surveillance data and published reports linking HPV vaccination to autonomic disorders. Results: At this time, the American Autonomic Society finds that there are no data to support a causal relationship between HPV vaccination and CRPS, chronic fatigue, and postural tachycardia syndrome to other forms of dysautonomia. Conclusion: Certain conditions are prevalent in the same populations that are vaccinated with the HPV vaccine (peri-pubertal males and females). This association, however, is an insufficient proof of causality.
KW - Autonomic dysfunction
KW - Consensus statement
KW - HPV
KW - Postural tachycardia syndrome
KW - Vaccine
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U2 - 10.1007/s10286-019-00608-w
DO - 10.1007/s10286-019-00608-w
M3 - Article
C2 - 31475305
AN - SCOPUS:85073800805
SN - 0959-9851
VL - 30
SP - 13
EP - 18
JO - Clinical Autonomic Research
JF - Clinical Autonomic Research
IS - 1
ER -