Human papillomavirus-related carcinomas of the sinonasal tract

Justin A. Bishop, Theresa W. Guo, David F. Smith, Hao Wang, Takenori Ogawa, Sara I. Pai, William H. Westra

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

High-risk human papillomavirus (HPV) is an established cause of head and neck carcinomas arising in the oropharynx. The presence of HPV has also been reported in some carcinomas arising in the sinonasal tract, but little is known about their overall incidence or their clinicopathologic profile. The surgical pathology archives of The Johns Hopkins Hospital were searched for all carcinomas arising in the sinonasal tract from 1995 to 2011, and tissue microarrays were constructed. p16 immunohistochemical analysis and DNA in situ hybridization for high-risk types of HPV were performed. Demographic and clinical outcome data were extracted from patient medical records. Of 161 sinonasal carcinomas, 34 (21%) were positive for high-risk HPV DNA, including type 16 (82%), type 31/33 (12%), and type 18 (6%). HPV-positive carcinomas consisted of 28 squamous cell carcinomas and variants (15 nonkeratinizing or partially keratinizing, 4 papillary, 5 adenosquamous, 4 basaloid), 1 small cell carcinoma, 1 sinonasal undifferentiated carcinoma, and 4 carcinomas that were difficult to classify but exhibited adenoid cystic carcinoma-like features. Immunohistochemistry for p16 was positive in 59/161 (37%) cases, and p16 expression strongly correlated with the presence of HPV DNA: 33 of 34 (97%) HPV-positive tumors exhibited high p16 expression, whereas only 26 of 127 (20%) HPV-negative tumors were p16 positive (P<0.0001). The HPV-related carcinomas occurred in 19 men and 15 women ranging in age from 33 to 87 years (mean, 54 y). A trend toward improved survival was observed in the HPV-positive group (hazard ratio=0.58, 95% confidence interval [0.26, 1.28]). The presence of high-risk HPV in 21% of sinonasal carcinomas confirms HPV as an important oncologic agent of carcinomas arising in the sinonasal tract. Although nonkeratinizing squamous cell carcinoma is the most common histologic type, there is a wide morphologic spectrum of HPV-related disease that includes a variant that resembles adenoid cystic carcinoma. The distinctiveness of these HPV-related carcinomas of the sinonasal tract with respect to risk factors, clinical behavior, and response to therapy remains to be clarified.

Original languageEnglish (US)
Pages (from-to)185-192
Number of pages8
JournalAmerican Journal of Surgical Pathology
Volume37
Issue number2
DOIs
StatePublished - Feb 1 2013

Fingerprint

Carcinoma
Adenoid Cystic Carcinoma
Squamous Cell Carcinoma
DNA
Surgical Pathology
Oropharynx
Small Cell Carcinoma
Medical Records
In Situ Hybridization
Neoplasms
Neck
Immunohistochemistry
Head
Demography
Confidence Intervals
Survival
Incidence

Keywords

  • adenoid cystic carcinoma
  • human papillomavirus
  • sinonasal carcinoma
  • sinonasal undifferentiated carcinoma
  • squamous cell carcinoma

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

Bishop, J. A., Guo, T. W., Smith, D. F., Wang, H., Ogawa, T., Pai, S. I., & Westra, W. H. (2013). Human papillomavirus-related carcinomas of the sinonasal tract. American Journal of Surgical Pathology, 37(2), 185-192. https://doi.org/10.1097/PAS.0b013e3182698673

Human papillomavirus-related carcinomas of the sinonasal tract. / Bishop, Justin A.; Guo, Theresa W.; Smith, David F.; Wang, Hao; Ogawa, Takenori; Pai, Sara I.; Westra, William H.

In: American Journal of Surgical Pathology, Vol. 37, No. 2, 01.02.2013, p. 185-192.

Research output: Contribution to journalArticle

Bishop, JA, Guo, TW, Smith, DF, Wang, H, Ogawa, T, Pai, SI & Westra, WH 2013, 'Human papillomavirus-related carcinomas of the sinonasal tract', American Journal of Surgical Pathology, vol. 37, no. 2, pp. 185-192. https://doi.org/10.1097/PAS.0b013e3182698673
Bishop, Justin A. ; Guo, Theresa W. ; Smith, David F. ; Wang, Hao ; Ogawa, Takenori ; Pai, Sara I. ; Westra, William H. / Human papillomavirus-related carcinomas of the sinonasal tract. In: American Journal of Surgical Pathology. 2013 ; Vol. 37, No. 2. pp. 185-192.
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abstract = "High-risk human papillomavirus (HPV) is an established cause of head and neck carcinomas arising in the oropharynx. The presence of HPV has also been reported in some carcinomas arising in the sinonasal tract, but little is known about their overall incidence or their clinicopathologic profile. The surgical pathology archives of The Johns Hopkins Hospital were searched for all carcinomas arising in the sinonasal tract from 1995 to 2011, and tissue microarrays were constructed. p16 immunohistochemical analysis and DNA in situ hybridization for high-risk types of HPV were performed. Demographic and clinical outcome data were extracted from patient medical records. Of 161 sinonasal carcinomas, 34 (21{\%}) were positive for high-risk HPV DNA, including type 16 (82{\%}), type 31/33 (12{\%}), and type 18 (6{\%}). HPV-positive carcinomas consisted of 28 squamous cell carcinomas and variants (15 nonkeratinizing or partially keratinizing, 4 papillary, 5 adenosquamous, 4 basaloid), 1 small cell carcinoma, 1 sinonasal undifferentiated carcinoma, and 4 carcinomas that were difficult to classify but exhibited adenoid cystic carcinoma-like features. Immunohistochemistry for p16 was positive in 59/161 (37{\%}) cases, and p16 expression strongly correlated with the presence of HPV DNA: 33 of 34 (97{\%}) HPV-positive tumors exhibited high p16 expression, whereas only 26 of 127 (20{\%}) HPV-negative tumors were p16 positive (P<0.0001). The HPV-related carcinomas occurred in 19 men and 15 women ranging in age from 33 to 87 years (mean, 54 y). A trend toward improved survival was observed in the HPV-positive group (hazard ratio=0.58, 95{\%} confidence interval [0.26, 1.28]). The presence of high-risk HPV in 21{\%} of sinonasal carcinomas confirms HPV as an important oncologic agent of carcinomas arising in the sinonasal tract. Although nonkeratinizing squamous cell carcinoma is the most common histologic type, there is a wide morphologic spectrum of HPV-related disease that includes a variant that resembles adenoid cystic carcinoma. The distinctiveness of these HPV-related carcinomas of the sinonasal tract with respect to risk factors, clinical behavior, and response to therapy remains to be clarified.",
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