Abstract
Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma is a peculiar sinonasal tract tumor that demonstrates features of both a surface-derived and salivary gland carcinoma. Implicit in its name, this tumor has a consistent association with high-risk HPV, particularly type 33. It was first described in 2013 under the designation of HPV-related carcinoma with adenoid cystic carcinoma-like features. However, since its initial description additional cases have emerged which demonstrate a wide morphologic spectrum and relatively indolent clinical behavior. Herein we report our experience with a case of HPV-related multiphenotypic sinonasal carcinoma that was initially classified as adenoid cystic carcinoma in the 1980s. The patient recurred after a 30-year disease free interval. RNA in situ hybridization confirmed the presence of high-risk HPV in both her recurrence and her initial tumor in the 1980s, which allowed for reclassification as HPV-related multiphenotypic sinonasal carcinoma. Our case adds to the literature of this relatively newly described entity and supports the indolent clinical behavior of this neoplasm but also demonstrates a potential for very late local recurrence.
Original language | English (US) |
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Pages (from-to) | 623-628 |
Number of pages | 6 |
Journal | Head and Neck Pathology |
Volume | 12 |
Issue number | 4 |
DOIs | |
State | Published - Dec 1 2018 |
Keywords
- Adenoid cystic carcinoma
- Carcinoma with adenoid cystic-like features
- Human papillomavirus
- Multiphenotypic sinonasal carcinoma
- Sinonasal carcinoma
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Otorhinolaryngology
- Oncology